Modified carbon paste electrode as a sensitive electrochemical sensor for quantification of chemotherapy drug imatinib
Abstract
The preferred tyrosine kinase inhibitor for treating gastrointestinal stromal tumours and chronic myeloid leukaemia is imatinib (IMT). Nevertheless, IMT has disadvantages, including resistance to the medication and notable variations in pharmacokinetics among patients. To address this problem, an analytical procedure for IMT determination was developed that incorporated MnMoO4@multi-walled carbon nanotubes (MWCNTs) into a carbon paste electrode (CPE) matrix to create an electrochemical sensing platform, MnMoO4@MWCNT/CPE. A hydrothermal technique was used to synthesize MnMoO4@MWCNT. Under carefully adjusted conditions, electrochemical characterization using differential pulse voltammetry showed a concentration interval with a linear response for IMT between 0.01 and 120.0 µM. In addition to a significant sensitivity of 0.3508 μA μM-1, quantitative analysis yielded detection ad quantification limits of 3 and 7 nM. The developed electrochemical probe demonstrated outstanding analytical performance, high stability, and repeatability when used to quantify IMT in pharmaceutical product samples.
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