Portable electrochemical sensor for adrenaline detection using CoNi-MOF-based CS-PAM hydrogel
Abstract
The development of a portable smartphone-based electrochemical sensor for analyzing adrenaline levels in real samples can make a great contribution to the research community worldwide. In order to achieve this goal, the key challenge is to build sensing interfaces with excellent electrocatalytic properties. In this work, microspherical bimetallic metal-organic frameworks (CoNi-MOF) consisting of nanoclusters were first synthesized using a hydrothermal method. On this basis, the catalytic activity of pure chitosan-polyacrylamide hydrogel (CS-PAM) was modulated by adding different amounts of CoNi-MOF during the in-situ synthesis of CS-PAM. Finally, a portable electrochemical detection system based on CS-PAM was established for the detection of adrenaline. A series of resulting composite hydrogels with a large specific surface area, abundant active sites, and unique network structure facilitate the enrichment and catalysis of adrenaline molecules. Under optimal conditions, the analytical platform constructed by using CoNi-MOF-based CS-PAM has the advantages of a wide detection range (0.5-10 and 10-2500 μM), a low detection limit (0.167 μM), and high sensitivity (0.182 and 0.133 μA·μM·cm-2). In addition, the sensor maintains selective detection of the target in the presence of many different types of interferences, and the current response is not significantly reduced even after 60 cycles of testing. We strongly believe that the designed smart portable sensing can realize the…
Read the paper
Related studies
- Nano Biosensors: Properties, applications and electrochemical techniques
- Electrochemically Synthesized MIP Sensors: Applications in Healthcare Diagnostics
- Toward a Harmonization for Using in situ Nutrient Sensors in the Marine Environment
- Electrochemical determination of rutin by using NiFe2O4 nanoparticles-loaded reduced graphene oxide
- Application of Polyoxometalate-based composites for sensor systems: A review
- Sensitive Electrochemical and Thermal Detection of Human Noroviruses Using Molecularly Imprinted Polymer Nanoparticles Generated against a Viral Target
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.