A Systematic Review of Electrochemical Sensing Devices Based on Metal-organic Frameworks for the Identification of Tumor Biomarkers
Abstract
Electrochemical sensors have attracted enormous interest in recent decades
due to their relatively simple synthesis process, the possibility of modifications in their composition,
and their wide application in detecting analytes.
To achieve excellent performance, materials used in its construction must facilitate the
transfer of electrons and provide a large surface area and excellent electrocatalytic activity. Because
they are functional nanomaterials, metal-organic frameworks (MOFs) meet the criteria for application
as a sensing material and can be used to build high-performance sensors for numerous applications.
They play a relevant role in the early diagnosis of various neoplasms and tumor processes,
thus providing better prognoses. Considering this universe, the present study focused on evaluating
the application of these nanomaterials in the recognition of tumor biomarkers.
A systematic review of scientific publications was performed using the following descriptors
"MOFs", "Metal-organic frameworks", "Biosensor", "Electrochemistry", and "Tumor Biomarker".
Herein, we analyze recent innovations of MOF-based biosensors applied to the detection
of tumor biomarkers, discussing how promising characteristics and properties of these materials
were harnessed in the development of biosensors to provide a new contribution to future studies
and the development of applied MOFs to electrochemical biosensing.
How strong is the evidence?
Evidence Hub reads this as a systematic review. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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