Effects of time-restricted eating on glycemic control and variability in individuals with overweight/obesity and prediabetes: A secondary analysis of the RESET randomized controlled trial
Abstract
AIM
The aim of this exploratory analysis was to investigate effects of time-restricted eating (TRE) on glycemic control and variability in adults with prediabetes.
METHODS
This study utilized data from the Restricted Eating Time (RESET) randomized controlled trial. A subset of 46 participants with prediabetes, allocated to either a 10-hour TRE intervention (n = 20) or the control group (n = 26), was analyzed. Changes in continuous glucose monitoring derived outcomes, fasting glucose and glycosylated hemoglobin (HbA1c), at 6 weeks and 3 months were assessed using a linear mixed-effects model.
RESULTS
There were no between-group differences in fasting glucose or HbA1c after 6 weeks and 3 months. The 24-hour and daytime coefficient of variation were reduced within the TRE group after 6 weeks but not after 3 months. Nighttime average sensor glucose was lower in the TRE group compared with the control group after 6 weeks [-0.3 mmol/L (-0.6 to -0.1)], but this effect was not maintained after 3 months [-0.1 mmol/L (-0.4 to 0.2)].
CONCLUSION
TRE may have a small short-term beneficial effect on nighttime glucose levels in adults with prediabetes. Larger long-term TRE studies are warranted.
How strong is the evidence?
Evidence Hub reads this as a secondary / pooled analysis, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 46 participants or records.
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