A Prospective Clinical Trial to find the Efficiency of the Therapeutic use of a Combination of Transdermal gels Producing CO2 in Treating Varicose Ulcers that do not Respond to Primary Treatment
Abstract
In this study, we evaluated 40 patients, all carriers of severe varicose ulcers. After four weeks of undergoing the same primary treatment, the progress was not as expected. We added two weekly applications, eight sessions in total, of transdermal carboxytherapy CO2-producing gels to their treatment primary regimen.
We assessed the patients through photos taken before applying the gels and after 4 and 6 weeks of the starting date.
We evaluated clinical manifestations, including the varicose ulcer's diameter and length, granulation, exudates, and pain.
The patients underwent an arterial and venous Echo Doppler before and immediately after the first application to rule out arterial involvement and to observe any changes in stroke flow at the microcirculatory level.
We measured the transcutaneous oxygen pressure (TcPO2) at a specific point for reference using a sensor before and after the first application and after the eighth application (one month later) of the gels (CO2PRO®) to see if transdermal carboxytherapy increased tissue oxygenation.
Purpose
This prospective study aims to evaluate the efficacy of a transdermal product (CO2PRO®) that, through a combination of gels, provides carbon dioxide to increase microcirculation and promote tissue oxygenation through the Bohr effect, helping to regenerate varicose ulcers.
Patients selected to enter the study were under primary ulcer treatment and were not responding as expected. The patients continued to use their primary…
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