Multiplexed Electrochemical Sensor for Real-Time Monitoring of Inflammatory Biomarkers
Abstract
This report presents a novel biochip for rapid and real-time detection of inflammatory biomarkers at the point-of-care. The biochip features a multiplexed electrochemical sensor of the size of a quarter. This report demonstrates the monitoring of two inflammatory biomarkers C-reactive protein and Interlukin-6, elevated levels of which is found to be associated with cardiovascular diseases, surgery-related mortality, and adverse clinical outcomes and death in critically ill severe acute respiratory syndrome coronavirus-2 patients. Our sensor exhibits high sensitivity with a detection limit of 6.6 attomolar and a response time of only 2 seconds. This project holds substantial societal benefit because the reported sensor will reduce the time to detection (which is especially critical in an under-resourced setting) and ensure continuous monitoring of biomarkers at the bedside. This device thus has the potential to manage future pandemics through early diagnosis, timely intervention, and isolation.
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