Molecularly Imprinted Electrochemical Sensor for Determination of Tetrahydrocannabinol in Human Blood Plasma
Abstract
The goal of this study was to create a molecular imprinting-based sensor on MWCNTs modified electrode for the selective determination of Δ 9 -tetrahydrocannabinol (Δ 9 -THC) as doping agent in biological fluids samples of athletes. as a doping agent in athlete biological fluid samples. The MWCNTs nanostructures were electrodeposited on the screen printed carbon electrode (MWCNTs/SPCE), and MIP was electropolymerized on the MWCNTs/SPCE surface (MIP/MWCNTs/SPCE). SEM and XRD analyses revealed that a thin layer of MIP particles covered MWCNTs without changing their morphology. Electrochemical studies using CV and DPV measurements revealed that MIP/MWCNTs nanostructured electrodes significantly improved electrocatalytic activity and electivity. Results demonstrated that the minimal detectable limit for Δ 9 THC was 0.37 ng/mL (S/N=3), the sensitivity of MIP/MWCNTs/SPCE THC was obtained at 0.00155 μA/ng.mL -1 , and linearity was over a concentration range of 0-3150 ng/mL with correlation coefficients of the standard curves > 0.99. The applicability and validity of MIP/MWCNTs/SPCE were investigated for Δ 9 -THC determination level in a cyclist's blood plasma sample, and results showed that the acceptable relative standard deviation (4.25%) and relative recovery (99.75%) values indicated that the developed method can be used for Δ 9 -THC determination level in clinical samples.
Read the paper
Related studies
- Nano Biosensors: Properties, applications and electrochemical techniques
- Electrochemically Synthesized MIP Sensors: Applications in Healthcare Diagnostics
- Toward a Harmonization for Using in situ Nutrient Sensors in the Marine Environment
- Electrochemical determination of rutin by using NiFe2O4 nanoparticles-loaded reduced graphene oxide
- Application of Polyoxometalate-based composites for sensor systems: A review
- Sensitive Electrochemical and Thermal Detection of Human Noroviruses Using Molecularly Imprinted Polymer Nanoparticles Generated against a Viral Target
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.