Serum Uric Acid-to-Creatinine Ratio Is Independently Associated with Sudomotor Dysfunction in Type 2 Diabetes: A Cross-Sectional Study
Abstract
Purpose This study investigated the association between the serum uric acid-to-creatinine ratio (SUA/Cr) and sudomotor dysfunction in patients with type 2 diabetes mellitus. Patients and Methods This was a single-center, inpatient, cross-sectional study. A total of 781 participants were classified into three tertiles based on their SUA/Cr. The electrochemical conductivity (ESC) of sweat obtained from the hands and feet was measured using SUDOSCAN to assess sudomotor function. Mean ESC values for the hands (HESC) and feet (FESC) were computed independently. Sudomotor dysfunction was defined as HESC or FESC ≤ 60 μS. Statistical analyses were performed using SPSS 25.0, involving one-way ANOVA, Kruskal–Wallis test, chi-square test, Spearman correlation coefficient, binary/multivariable logistic regression (with three adjusted models), and subgroup analysis, with statistical significance defined as p 0.05). Conclusion The SUA/Cr ratio is independently associated with sudomotor dysfunction in patients with type 2 diabetes mellitus.
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 781 participants or records.
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