Intraocular Pressure Monitoring Using An Implantable Sensor Detects Structural Glaucoma Progression in the EYEMATE-IO Trial
Abstract
OBJECTIVE AND PURPOSE
To evaluate the association between intraocular pressure (IOP) measurements and concurrent rates of retinal nerve fiber layer (RNFL) thinning in primary open-angle glaucoma (POAG) eyes previously implanted with a sulcus-based IOP sensor.
DESIGN
This case series is part of the prospective, open-label, multicenter interventional EYEMATE-SC trial.
SUBJECTS, PARTICIPANTS, AND/OR CONTROLS
Patients implanted with the EYEMATE-IO sensor system (Implandata, Hanover, Germany) were enrolled in the 3 years' ARGOS-03 follow-up study.
METHODS, INTERVENTION, OR TESTING
All patients enrolled had at least five optical coherence tomography (OCT) examinations six-months apart with minimum two years follow-up. A minimum of 4 IOP measurements daily at different times of the day were obtained with the EYEMATE-IO.
MAIN OUTCOME MEASURES
Mean IOP, peak IOP, and fluctuation of IOP measured by EYEMATE-IO sensor during the period between two consecutive OCT examinations were calculated and the relationship with OCT RNFL thinning was analyzed using mixed effects models. The relationship of mean IOP measured by Goldmann applanation tonometry (GAT) on the day of OCT visit with RNFL thinning was also analyzed.
RESULTS
Eight eyes of 8 patients with the EYEMATE-IO sensor were included in the analysis. The mean number of self-measurements of IOP per patient was 7283 ± 5562 (range 1478 to 17247), with a mean follow-up time of 2.88 ± 0.19 years (range 2.43 to 3.01). The mean number of OCT…
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health. Reported size: 8 participants or records.
Read the paper
Related studies
- Nano Biosensors: Properties, applications and electrochemical techniques
- Electrochemically Synthesized MIP Sensors: Applications in Healthcare Diagnostics
- Toward a Harmonization for Using in situ Nutrient Sensors in the Marine Environment
- Electrochemical determination of rutin by using NiFe2O4 nanoparticles-loaded reduced graphene oxide
- Application of Polyoxometalate-based composites for sensor systems: A review
- Sensitive Electrochemical and Thermal Detection of Human Noroviruses Using Molecularly Imprinted Polymer Nanoparticles Generated against a Viral Target
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.