An All-in-One Au@CeO2 Nanozyme Platform for Synergistic Detection and Photocatalytic Conversion of Uric Acid
Abstract
Precise monitoring and regulation of uric acid in synovial fluid is crucial for understanding uric acid-related pathological environments. Here, we construct and evaluate a bifunctional Au@CeO2 nanorod nanozyme platform that integrates ultrasensitive electrochemical sensing with photoelectrochemically driven uric acid degradation. The core-shell architecture couples plasmonic Au with catalytically active CeO2, facilitating detection of uric acid down to sub-nanomolar levels and effective catalytic degradation via ROS (*OH, *OO-, and 1O2). In situ Raman, EPR, and DFT studies provide insights into enhanced charge transfer and catalytic mechanisms at the heterointerface. Furthermore, the platform demonstrates coupled uric acid sensing and degradation performance in a simulated synovial fluid environment. Overall, this study provides a proof-of-concept demonstration of a nanozyme-based electrochemical platform for integrated uric acid sensing and regulation under laboratory conditions and establishes a foundation for future investigations toward localized biofluid monitoring and modulation.
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