A Powerful Electrochemical Sensor Based on Fe2O3 nanoparticle-Graphene Oxide Nanocomposites for Determination of Metronidazole as an Antibacterial Drug
Abstract
This research focused on the hydrothermal synthesis of Fe2O3 nanoparticle-Graphene oxide nanocomposites modified glassy carbon electrode (Fe2O3@GO/GCE) as an electrochemical sensor for determining the antibacterial medication Metronidazole (MNZ). Fe2O3@GO nanocomposite production was confirmed by SEM and XRD studies. Electrochemical studies using DPV and amperometry techniques revealed that Fe2O3@GO/GCE as a sensitive and selective MNZ sensor had comparable and even better sensing performance than previously reported MNZ sensors, which was attributed to Fe2O3@GO nanocomposite's synergistic electrocatalytic effects for MNZ electrochemical sensing. The liner range, the sensitivity and the detection limit were estimated at 1 to 1680μM, 0.02289μA/μM and 55nM, respectively. The validity and precision of the proposed amperometry sensing method for determining MNZ were evaluated in five different urine samples from patients aged 45-60 years old who were given MNZ, and the findings of the amperomery and ELISA assays were found to be in good agreement, implying that the proposed system had high detection accuracy and validity for determining MNZ in clinical samples.
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