Electrochemical Sensor for Meropenem Therapeutic Monitoring in Human Plasma Based on Carbon Nanotubes Modified Basal Pyrolytic Graphite Electrode
Abstract
A sensitive, precise, and fast differential pulse voltammetric method has been developed for determination of meropenem (MER) in pure form, pharmaceutical dosage form, and human plasma. The fabricated sensors are based on basal-plane pyrolytic graphite electrode substrates that was modified by coating the surface with carbon nanotubes. The modified electrode showed detectable enhancement of the anodic peak current of meropenem from 25.8 to 35.7 µA. The effect of both pH and scan rate on peak current and potential were studied, and the optimum conditions were found to be at pH = 3.0 and scan rate of 100 mV.s-1. A linear response was obtained over the concentration range of 3.0×10-7 to 7.0×10-5 M MER in an aqueous buffer solution. The suggested sensor is highly sensitive, has a short response time, and is capable of MER detection as low concentration as 1.5×10-6 M in human plasma. The proposed sensor shows a great potential towards future fabrication of a point-of-care device to monitor MER level in patients’ plasma to ensure drug safety and efficacy for patients in intensive care unit.
Read the paper
Related studies
- Nano Biosensors: Properties, applications and electrochemical techniques
- Electrochemically Synthesized MIP Sensors: Applications in Healthcare Diagnostics
- Toward a Harmonization for Using in situ Nutrient Sensors in the Marine Environment
- Electrochemical determination of rutin by using NiFe2O4 nanoparticles-loaded reduced graphene oxide
- Application of Polyoxometalate-based composites for sensor systems: A review
- Sensitive Electrochemical and Thermal Detection of Human Noroviruses Using Molecularly Imprinted Polymer Nanoparticles Generated against a Viral Target
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.