Nanopot V1.0: A point of care electrochemical sensor prototype device for precise detection of tacrolimus in transplant patients
Abstract
A miniaturized electrochemical sensor device prototype (NanoPot V1.0) encompasses with a portable potentiostat was developed for precise detection of tacrolimus, which is a critical immunosuppressant drug used for prevention of organ rejection in transplant patients. The developed NanoPot V1.0 prototype device combines a LMP91000 analog front-end with a ESP8266 microcontroller on a compact circuit board, along with a cylindrical well comprising of three electrode system with carbon cloth as working electrode. Notably, the chronoamperometric results from NanoPot V1.0 prototype device were very similar to those from a regular conventional CH Instruments potentiostat, which proved that he developed prototype device is accurate and reliable. The electrochemical behaviour of tacrolimus using NanoPot V1.0 prototype device was evaluated across a concentration range of 5 - 50 nM, which comes under clinically relevant levels. The prototype device showed excellent linearity with a detection limit comparable to standard laboratory equipment with excellent linearity (R 2 = 0.99) in tacrolimus quantification, with a detection limit comparable to standard laboratory equipment. Hence, this NanoPot V1.0 prototype device is bridging the gap between sophisticated laboratory-grade instruments and portable point-of-care (PoC) devices. This work represents a significant step towards developing a portable, sensitive, low-cost, and reliable PoC device for tacrolimus monitoring. This combination of…
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