Ciprofloxacin Electrochemical Sensor Using Copper–Iron Mixed Metal Oxides Nanoparticles/Reduced Graphene Oxide Composite
Abstract
The harmful effects of antibiotic proliferation on the environment and its persistent nature are urgent global problems. Ciprofloxacin (CIP) is a fluoroquinolone-class antibiotic agent used widely to treat pathogen-related diseases in humans and animals. Its excretion into surface water causes antibiotic resistance in microbes, resulting in difficult-to-treat or untreatable infectious diseases. This study developed a simple and efficient electrochemical sensor to detect CIP. Hydrothermal chemistry was utilized to synthesize an electrophotocatalytic composite of copper–iron mixed metal oxides (CIMMO) on reduced graphene oxide (rGO) (CIMMO/rGO). The composite was employed in an electrochemical sensor and exhibited outstanding performance in detecting CIP. The sensor was operated in differential pulse voltammetry (DPV) mode under light source illumination. The sensor yielded a linear response in the concentration range of 0.75 × 10–9–1.0 × 10–7 mol L–1 CIP and showed a limit of detection (LOD) of 4.74 × 10–10 mol L–1. The excellent sensing performance of the composite is attributable to the synergic effects between CIMMO nanoparticles and rGO, which facilitate photoinduced electron–hole separation and assist in the indirect electrochemical reactions/interactions with CIP.
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