Integration of electrochemical sensors in organ-on-a-chip microfluidic platforms: Advances and perspectives
Abstract
Electrochemical sensors integrated into organ-on-a-chip (OoC) - single-organ systems and more complex multi-organ (body-on-a-chip) - microfluidic platforms constitute a rapidly advancing interface between biosensing, microfluidics, and microphysiological systems (MPS), with major implications for biomedical research, drug discovery, toxicology, and personalized medicine. By transducing biochemical and biophysical events at the tissue-device interface into quantifiable electrical signals, these sensors enable real-time, label-free, and highly sensitive monitoring of metabolites, ions, barrier integrity, and cellular activity under physiologically relevant conditions. Within OoC and MPS platforms, electrochemical sensing can be implemented through different integration strategies, including on-chip configurations such as in-line and on-line sensing directly embedded within microfluidic channels, as well as off-chip approaches. The integration of miniaturized and multiplexed electrochemical sensors into MPS enables continuous and high-throughput functional monitoring of key physiological parameters, including metabolic activity variation, biomolecules gradients, barrier function, and responses to drugs and toxic compounds. Multi-OoC configurations benefit from electrochemical readouts to interrogate dynamic inter-organ communication and systemic responses, supporting more predictive human-relevant models. This is mostly relevant for new approach methodologies (NAMs), which aim…
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