Multiphysics-guided design of ZIF-67/MWCNT-modified electrodes for highly selective electrochemical detection of sunset yellow in complex food matrices
Abstract
The development of reliable sensing platforms for synthetic food additives remains a critical challenge due to severe matrix interferences that limit selectivity and analytical accuracy. In this work, a multiphysics-guided framework is employed to design a ZIF-67/MWCNT-modified glassy carbon electrode (GCE) for the highly selective electrochemical detection of sunset yellow (SY) in complex food matrices. By integrating experimental electrochemical analysis with COMSOL-based modeling of mass transport, adsorption dynamics, charge transfer, and thermal effects, this study provides a mechanistic basis for material-analyte interactions that govern sensor performance. The ZIF-67/MWCNT hybrid exhibits synergistic surface chemistry, where π-π stacking between the azo-aromatic structure of SY and the graphitic domains of MWCNTs, together with electrostatic interactions with Co2+ centers in ZIF-67, yields a high adsorption constant (K ads = 5.41 × 104 m3 mol-1) and a dominant surface flux (3.47 × 10-7 mol m-2 s-1), surpassing those of common interferents. The optimized electrode delivers a steady-state current density of 5.22 µA m-2 at pH 7 and a 5 µm composite layer, while maintaining negligible faradaic contributions from ascorbic acid, citric acid, aspartame, and acesulfame potassium. Parametric simulations reveal robust performance under thermal variations (298-328 K), minimal sensitivity to electrolyte disturbances, and a direct correlation between surface heterogeneity and…
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