A robust Au-C[triple bond, length as m-dash]C anchoring group greatly improves the signal stability of electrochemical aptamer-based sensors for in vivo measurements
Abstract
The ability to monitor drug pharmacokinetics in real time and directly in vivo is critical to achieve therapeutic efficacy and personalized medicine. Electrochemical aptamer-based (EAB) sensors have emerged as a promising platform for this purpose, yet their long-term stability is compromised by the degradation of the conventional Au-S bond-based bioelectronic interface under continuous interrogation. To address this fundamental limitation, we introduced an approach based on an Au-C[triple bond, length as m-dash]C anchoring group to create a significantly more robust sensing interface. This stable configuration enabled our sensors to retain 92% signal integrity over 72 hours (>6000 scans) in whole blood. Leveraging this exceptional stability, we successfully achieved real-time tracking of drug concentrations in live rats, demonstrating a significant advance toward continuous pharmacokinetic monitoring.
Read the paper
Related studies
- Nano Biosensors: Properties, applications and electrochemical techniques
- Electrochemically Synthesized MIP Sensors: Applications in Healthcare Diagnostics
- Toward a Harmonization for Using in situ Nutrient Sensors in the Marine Environment
- Electrochemical determination of rutin by using NiFe2O4 nanoparticles-loaded reduced graphene oxide
- Application of Polyoxometalate-based composites for sensor systems: A review
- Sensitive Electrochemical and Thermal Detection of Human Noroviruses Using Molecularly Imprinted Polymer Nanoparticles Generated against a Viral Target
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.