Carbon-Based Electrochemical Sensors for In Vivo and In Vitro Neurotransmitter Detection
Abstract
As essential neurological chemical messengers, neurotransmitters play an integral role in the maintenance of normal mammalian physiology. Aberrant neurotransmitter activity is associated with a range of neurological conditions including Parkinson's disease, Alzheimer's disease, and Huntington's disease. Many studies to date have tested different approaches to detecting neurotransmitters, yet the detection of these materials within the brain, due to the complex environment of the brain and the rapid metabolism of neurotransmitters, remains challenging and an area of active research. There is a clear need for the development of novel neurotransmitter sensing technologies capable of rapidly and sensitively monitoring specific analytes within the brain without adversely impacting the local microenvironment in which they are implanted. Owing to their excellent sensitivity, portability, ease-of-use, amenability to microprocessing, and low cost, electrochemical sensors methods have been widely studied in the context of neurotransmitter monitoring. The present review, thus, surveys current progress in this research field, discussing developed electrochemical neurotransmitter sensors capable of detecting dopamine (DA), serotonin (5-HT), acetylcholine (Ach), glutamate (Glu), nitric oxide (NO), adenosine (ADO), and so on. Of these technologies, those based on carbon nanostructures-modified electrodes including carbon nanotubes (CNTs), graphene (GR), gaphdiyne (GDY), carbon nanofibers…
Read the paper
Related studies
- Nano Biosensors: Properties, applications and electrochemical techniques
- Electrochemically Synthesized MIP Sensors: Applications in Healthcare Diagnostics
- Toward a Harmonization for Using in situ Nutrient Sensors in the Marine Environment
- Electrochemical determination of rutin by using NiFe2O4 nanoparticles-loaded reduced graphene oxide
- Application of Polyoxometalate-based composites for sensor systems: A review
- Sensitive Electrochemical and Thermal Detection of Human Noroviruses Using Molecularly Imprinted Polymer Nanoparticles Generated against a Viral Target
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.