New opportunities for nanotechnology in the field of diagnostics based on proteomics
Abstract
New developments in personalised medicine pose a technological challenge for the implementation of diagnostic devices demanding an increase for the speed, throughput and sensitivity for the detection of proteomic biomarkers. Following the tracks of genetics where the progress came through the analysis of DNA fragments, peptides, which are small fragments of proteins, can provide a new tool to get insights into the analysis of macromolecules. However, the current methods of combinatorial chemistry and sensing based on liquid handling and labelling, respectively, cannot cope with the demands of throughput and speed required by clinical applications. Nanotechnology holds promises to improve in-situ synthesis of microarrays and label free sensing to provide the combinatorial flexibility, quickness and sensitivity to help for the implementation of proteomic diagnosis in precision medicine. *Correspondence to: García CP, Nano-Enabled Medicine and Cosmetics group, Materials Research and Technology Department, Luxembourg Institute of Science and Technology (LIST), 41, rue du Brill, Belvaux, Luxembour, E-mail: [email protected] Special Issue: Nanotechnology: Challenges and Perspectives in Medicine Dr. Federica Valentini Department of Sciences and Chemical Technologies Tor Vergata University Italy Maurizio Talamo Professor Department of Enterprise Engineering Italy Received: November 25, 2018; Accepted: December 20, 2018; Published: December 24, 2018 Introduction During the last…
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