Evaluation of HCC Response to Systemic Therapy With Quantitative MRI
Abstract
The incidence of hepatocellular carcinoma (HCC) has recently increased in the United States. Although imaging plays a major role in HCC screening and staging, the possibility of predicting HCC tumor grade, aggressiveness, angiogenesis and hypoxia with imaging are unmet needs. In addition, new antiangiogenic drugs now available to treat advanced HCC necessitate the use of new imaging criteria beyond size. The investigators would like to develop and validate non-invasive magnetic resonance imaging (MRI) methods based on advanced diffusion-weighted imaging (DWI), MR Elastography, BOLD (blood oxygen level dependent) MRI and perfusion-weighted imaging (PWI, using gadolinium contrast) to be used as non-invasive markers of major histopathologic features of HCC, and to predict and assess early response of HCC to systemic therapy. The investigators also would like to develop quality control tools to improve the quality and decrease variability of quantitative MRI metrics. These techniques combined could represent non-invasive correlates of histologic findings in HCC, could enable individualized therapy, and provide prognosis in patients with HCC.
Conditions: Hepatocellular Carcinoma, HCC.
Primary outcome: SubStudy 1: Apparent Diffusion Coefficient (ADC); SubStudy 1: Total Tumor Perfusion (Ft); SubStudy 1: Tumor Arterial Perfusion Fraction (ART); SubStudy 1: Tumor Mean Transit Time (MTT); SubStudy 1: Tumor Distribution Volume (DV); SubStudy 1: Oxygen Uptake; SubStudy 1: Percent Change…
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 84 participants or records.
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