Skeletal Health and Bone Marrow Composition Among Youth
Abstract
Children and adolescents experiencing gender dysphoria feel increased distress with the onset of puberty. Gender clinics treat these young adolescents by "blocking" puberty using gonadotropin-releasing hormone (GnRH) agonist medications. This has the possibility of impacting bone development as sex steroids are important to bone mass development. In this multi-site study, the investigators will examine bone marrow composition (by MRI) in 40 transgender youth and bone density and body composition before/after pubertal blockade compared to healthy participants.
Conditions: Gender Dysphoria in Children, Puberty, Bone Development.
Primary outcome: Change from Bone marrow adiposity by magnetic resonance imaging (MRI) from baseline compared to 24 months; Change from magnetic resonance spectroscopy (MRS) from baseline compared to 24 months.
Enrollment: 78 participants.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 78 participants or records.
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