Browse studies, page 1062

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Effect of metformin on plasma metabolite profile in the Copenhagen Insulin and Metformin Therapy (CIMT) trial Diabetic medicine : a journal of the British Diabetic Association, 2018
A Randomized Controlled Trial of R-Form Verapamil Added to Ongoing Metformin Therapy in Patients with Type 2 Diabetes Journal of Clinical Endocrinology and Metabolism, 2022
Differential effects of imeglimin and metformin on insulin and incretin secretion—An exploratory randomized controlled trial Diabetes, obesity and metabolism, 2024
Effects of exercise training and metformin on body composition and cardiovascular indices in HIV-infected patients AIDS (London, England), 2004
Metformin for neurocognitive dysfunction in schizophrenia: a systematic review Frontiers in Psychiatry, 2025
The different hypoglycemic effects between East Asian and non-Asian type 2 diabetes patients when treated with SGLT-2 inhibitors as an add-on treatment for metformin: a systematic review and meta-analysis of randomized controlled trials Aging, 2021
Effect of vitamin D supplementation on polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials Complementary therapies in clinical practice, 2017
Pharmacological strategies to counteract antipsychotic-induced weight gain and metabolic adverse effects in schizophrenia: a systematic review and meta-analysis Schizophrenia bulletin, 2014
Dipeptidyl peptidase-4 inhibitors for treatment of type 2 diabetes mellitus in the clinical setting: systematic review and meta-analysis BMJ (Clinical research ed.), 2012
Systematic Review with Network Meta-Analysis: Antidiabetic Medication and Risk of Hepatocellular Carcinoma Scientific reports, 2016
Status of clomiphene citrate and metformin for infertility in PCOS. Trends in endocrinology and metabolism: TEM, 2012
The effects of myo-inositol vs. metformin on the ovarian function in the polycystic ovary syndrome: a systematic review and meta-analysis European review for medical and pharmacological sciences, 2021
Efficacy and safety of metformin in the management of type 2 diabetes mellitus in older adults: a systematic review for the development of recommendations to reduce potentially inappropriate prescribing BMC geriatrics, 2017
Hypoglycaemia when adding sulphonylurea to metformin: a systematic review and network meta-analysis British journal of clinical pharmacology, 2016
Efficacy and safety of glucagon-like peptide-1 receptor agonists in the treatment of polycystic ovary syndrome-A systematic review and meta-analysis Archives of physiology and biochemistry, 2024
Iatrogenic hyperhomocysteinemia in patients with metabolic syndrome: a systematic review and metaanalysis Atherosclerosis, 2011
Evaluation of guideline recommendations on oral medications for type 2 diabetes mellitus: a systematic review Annals of internal medicine, 2012
Effect of metformin use on the risk and prognosis of colorectal cancer in diabetes mellitus: a meta-analysis Anti-cancer drugs, 2022
Effectiveness of sitagliptin compared to sulfonylureas for type 2 diabetes mellitus inadequately controlled on metformin: a systematic review and meta-analysis BMJ open, 2017
The effects of Diane-35 and metformin in treatment of polycystic ovary syndrome: an updated systematic review Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2008
Oral anti-diabetic agents for women with established diabetes/impaired glucose tolerance or previous gestational diabetes planning pregnancy, or pregnant women with pre-existing diabetes The Cochrane database of systematic reviews, 2017
Genetic polymorphisms of organic cation transporter 1 (OCT1) and responses to metformin therapy in individuals with type 2 diabetes: A systematic review Medicine, 2018
Risk of foetal harm with letrozole use in fertility treatment: a systematic review and meta-analysis Human reproduction update, 2021
Effects of Metformin on Risk and Prognosis of Biliary Tract Cancer: A Systematic Review and Meta-Analysis Medicina (Kaunas, Lithuania), 2023
Factors influencing the anticancer effects of metformin on breast cancer outcomes: a systematic review and meta-analysis Expert review of anticancer therapy, 2022
Role of metformin in overweight and obese people without diabetes: a systematic review and network meta-analysis European journal of clinical pharmacology, 2019
Impact of metformin on the risk and treatment outcomes of tuberculosis in diabetics: a systematic review BMC infectious diseases, 2019
Metformin With or Without Clomiphene Citrate Versus Laparoscopic Ovarian Drilling With or Without Clomiphene Citrate to Treat Patients With Clomiphene Citrate-Resistant Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis Frontiers in pharmacology, 2022
Efficacy of N-Acetylcysteine in Polycystic Ovary Syndrome: Systematic Review and Meta-Analysis Nutrients, 2025
Gonadotrophins for ovulation induction in women with polycystic ovarian syndrome The Cochrane database of systematic reviews, 2015
Antidiabetic medications and the risk of colorectal cancer in patients with diabetes mellitus: a systematic review and meta-analysis Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2013
Association Between Metformin and Alzheimer's Disease: A Systematic Review and Meta-Analysis of Clinical Observational Studies Journal of Alzheimer's disease : JAD, 2022
Metformin prescription and aortic aneurysm: systematic review and meta-analysis Heart (British Cardiac Society), 2019
Antidiabetic medications and the risk of prostate cancer in patients with diabetes mellitus: A systematic review and meta-analysis Pharmacological research, 2022
Impact of pharmacological interventions on anthropometric indices in women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials Clinical endocrinology, 2022
The Effect of Thiazolidinediones in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis of Randomised Controlled Trials Advances in therapy, 2024
Treatment of Pediatric Obesity: An Umbrella Systematic Review The Journal of clinical endocrinology and metabolism, 2017
The identification and treatment of women with hyperglycaemia in pregnancy: an analysis of individual participant data, systematic reviews, meta-analyses and an economic evaluation Health technology assessment (Winchester, England), 2016
A systematic review and meta-analysis of randomised controlled trials of treatments for clozapine-induced obesity and metabolic syndrome European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2016
The Potential Use of Metformin, Dipyridamole, N-Acetylcysteine and Statins as Adjunctive Therapy for Systemic Lupus Erythematosus Cells, 2019
Metformin monotherapy for type 2 diabetes mellitus The Cochrane database of systematic reviews, 2005
Laser and Light-Based Therapies for Hirsutism Management in Women With Polycystic Ovarian Syndrome: A Systematic Review JAMA dermatology, 2024
Metformin for endometrial hyperplasia The Cochrane database of systematic reviews, 2017
Second-line therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy: a systematic review and mixed-treatment comparison meta-analysis Open medicine : a peer-reviewed, independent, open-access journal, 2011
A Systematic Review and Meta-Analysis of Randomized Controlled Trials Comparing the Effects of Biguanides (Metformin) and Thiazolidinediones on Glucose Tolerance and Insulin Sensitivity in Patients With Type II Diabetes Mellitus Cureus, 2023
Reduced colorectal cancer incidence in type 2 diabetic patients treated with metformin: a meta-analysis Pharmaceutical biology, 2016
Disparities in the Efficacy of Metformin in Combination with Dipeptidyl Peptidase-4 Inhibitor as Initial Treatment Stratified by Dosage and Ethnicity: A Meta-Analysis Diabetes technology & therapeutics, 2018
The effect of metformin on anthropometrics and insulin resistance in patients receiving atypical antipsychotic agents: a meta-analysis The Journal of clinical psychiatry, 2010
Comparative effects of sitagliptin and metformin in patients with type 2 diabetes mellitus: a meta-analysis Current medical research and opinion, 2013
Genetic Variants Involved in Metformin Pharmacokinetics in the Chilean Population Genes, 2026
Dose-dependent histopathological and immunohistochemical effects of metformin in experimental osteoarthritis Clinical rheumatology, 2026
NR4A1-Driven Granulosa Cell Ferroptosis Contributes to Obesity-Related Ovarian Dysfunction and Metformin-Mediated Ovarian Protection FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026
Metformin restores marrow mesenchymal lineage homeostasis in glucocorticoid-induced osteoporosis through a gut microbiota–butyrate–ERK1/2 axis 2026
MCT6 is an intestinal Lac-Phe exporter required for metformin-associated weight loss 2026
Drug–Drug Interaction Assessment of WXFL10203614 with Rifampicin, Itraconazole and Metformin: A Three-Cohort Phase I Study 2026
A Multicenter, Randomized, Double Blind (Double Dummy), Active Controlled Study to Compare the Safety, Tolerability and Effect on Glycemic Control of Taspoglutide Versus Pioglitazone in Type 2 Diabetes Patients Inadequately Controlled on Therapy With Sulfonylurea or Metformin Plus Sulfonylurea ClinicalTrials.gov · COMPLETED, 2010
Modulation of Response to Hormonal Therapy With Lapatinib and/or Metformin in Patients With HER2-negative, ER and/or PgR Positive Metastatic Brest Cancer With Progressive Disease After First-line Therapy ClinicalTrials.gov · TERMINATED, 2013
Mechanisms of Improved Wound Healing and Protein Synthesis of Insulin and Metformin ClinicalTrials.gov · TERMINATED, 2019
A Combined Single Dose Study Under Fasting Condition And Multiple Doses Study Under Normal Diabetic Meal Comparing the Bioavailability of Two Formulations of 500 mg Metformin Hydrochloride Extended Release Tablets ClinicalTrials.gov · COMPLETED, 2010
Bioequivalence Study of the Fixed Dose Combination of 2.5 mg Saxagliptin and 850 mg Metformin Tablet Relative to a 2.5 mg Saxagliptin (Onglyza) Tablet and a 850 mg Metformin (Glucophage Marketed by Merck Serono) Tablet Co-Administered to Healthy Subjects in the Fasted and Fed Conditions ClinicalTrials.gov · COMPLETED, 2010
A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter 24-week Study Followed by an Extension Assessing the Efficacy and Safety of AVE0010 on Top of Metformin in Patients With Type 2 Diabetes Not Adequately Controlled With Metformin ClinicalTrials.gov · COMPLETED, 2011
A 12-week, phase 2A, randomized, double-blind, sponsor-open, placebo-controlled, parallel group study to assess the safety, tolerability, and pharmacodynamics of PF-06882961 titration in adults with type 2 diabetes mellitus treated with metformin and in NON-diabetic adults with obesity ClinicalTrials.gov · COMPLETED, 2021
Uterine Artery Blood Flow in Pregnant Women With Polycystic Ovary Syndrome(PCOS)Treated With Metformin - a Substudy to The PregMet Study ClinicalTrials.gov · COMPLETED, 2010
A 52-Week International, Multi-centre, Randomized, Parallel-group, Double-blind, Active-controlled, Phase III Study With a 52-Week Extension Period to Evaluate the Safety and Efficacy of Saxagliptin in Combination With Metformin Compared With Sulphonylurea in Combination With Metformin in Adult Patients With Type 2 Diabetes Who Have Inadequate Glycaemic Control on Metformin Therapy Alone ClinicalTrials.gov · COMPLETED, 2010
Phase II Trial of Nivolumab and Metformin in Patients With Treatment Refractory MSS Metastatic Colorectal Cancer ClinicalTrials.gov · COMPLETED, 2021
Impact of Pioglitazone, Metformin and the Combination of Both on Cardiovascular Risk in Insulin-treated Patients With Type 2 Diabetes - The PIOcomb Study ClinicalTrials.gov · COMPLETED, 2010
A Multicenter, Randomized, Double-Blind Study to Evaluate the Safety and Efficacy of the Addition of MK0431 to Patients With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Pioglitazone Therapy ClinicalTrials.gov · COMPLETED, 2005
A Randomized, Double Blind Placebo Controlled Clinical Trial to Assess the Efficacy and Safety of Sitagliptin on Bone Measures in Women Affected by Type 2 Diabetes. a Gender-oriented Approach to Address a Gender-specific Frailty: the SLowDOWN (SitagLiptin in Diabetes for Osteoporosis in WomeN) Study ClinicalTrials.gov · COMPLETED, 2024
PGC-1 & Muscle Mitochondrial Dysfunction in Diabetes ClinicalTrials.gov · TERMINATED, 2016
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Phase 3 Trial to Evaluate the Safety and Efficacy of Therapy With Dapagliflozin Added to Saxagliptin in Combination With Metformin Compared to Therapy With Placebo Added to Saxagliptin in Combination With Metformin in Subjects With Type 2 Diabetes Who Have Inadequate Glycemic Control on Metformin and Saxagliptin ClinicalTrials.gov · COMPLETED, 2015
Effect of Adding Metformin to Insulin Therapy in Pregnant Women With Type I Diabetes as Regards Pregnancy Outcome ClinicalTrials.gov · COMPLETED, 2020
A Randomised Placebo Controlled Trial of the Effectiveness of Early MEtformin in Addition to Usual Care in the Reduction of Gestational Diabetes Mellitus Effects (EMERGE) ClinicalTrials.gov · COMPLETED, 2023
A Randomized Double-blind Study to Determine the Effect of GK Activator (2) on Efficacy (HbA1c), Safety, Tolerability and Pharmacokinetics in Patients With Type 2 Diabetes Mellitus Treated With a Stable Dose of Metformin ClinicalTrials.gov · COMPLETED, 2007
A Phase 1, Open-Label Study to Evaluate the Relative Bioavailability and the Effect of Food on VH4524184 Tablet Formulations, and to Evaluate the Potential for VH4524184 Drug-Drug-Interactions in Healthy Adult Participants ClinicalTrials.gov · COMPLETED, 2025
Effect of CagriSema, Semaglutide and Cagrilintide on Insulin Sensitivity and Pancreatic Endocrine Function in Adults With Type 2 Diabetes ClinicalTrials.gov · COMPLETED, 2026
1% Metformin Gel as Local Drug Delivery in the Treatment of Class II Furcation Defects: A Randomized Controlled Clinical Trial ClinicalTrials.gov · COMPLETED, 2015
Gestational Diabetes in Non Obese Women and Metformine ClinicalTrials.gov · TERMINATED, 2018
Effect of Inflammatory Axis and Sirtuins' Expression in a Population of Overweight Pre-diabetics Patients From Metabolic Homeostasis Towards the Adipogonesis, and to Cardiac Redomelling ClinicalTrials.gov · COMPLETED, 2018
An Open-label, Randomized Two-arm Parallel Group Study to Compare the Effects of 4-week QD Treatment With Lixisenatide or Liraglutide on the Postprandial Plasma Glucose in Patients With Type 2 Diabetes Not Adequately Controlled With Metformin ClinicalTrials.gov · COMPLETED, 2010
A Randomized, 24 Week, Active-controlled, Open-label, 3-arm, Parallel-group Multicenter Study Comparing the Efficacy and Safety of iGlarLixi to Insulin Glargine and Lixisenatide in Type 2 Diabetes Mellitus Patients Insufficiently Controlled With Oral Antidiabetic Drug(s) ClinicalTrials.gov · COMPLETED, 2021
A 20-week Study Comparing Patient-adjusted Versus Physician-adjusted Titration of BIAsp 30 Combined With Metformin in Type 2 Diabetes Patients Uncontrolled on NPH Insulin ClinicalTrials.gov · COMPLETED, 2015
A Phase 3, Randomized, Double-Blind, Active-Controlled, Multicenter Trial to Evaluate the Safety and Efficacy of BMS-298585 in Combination With Metformin Compared to Pioglitazone in Combination With Metformin in Type 2 Diabetics With Inadequate Glycemic Control on Metformin Alone ClinicalTrials.gov · COMPLETED
The Efficacy of Insulin Degludec/Liraglutide as add-on Therapy in Controlling Glycaemia in Adults With Type 2 Diabetes Inadequately Controlled on Sulphonylurea With or Without Metformin Therapy ClinicalTrials.gov · COMPLETED, 2013
Comparative Effects of Exercise and Metformin on Glycemic Control in Prediabetic Adults: A Community-Based, Open-Label, Randomized Trial in a Low-Resource Setting ClinicalTrials.gov · COMPLETED, 2026
An Open-label, Randomised, Two-period Crossover Study to Assess the Effect of Dapagliflozin on Percent Inhibition of Glucose Re-absorption When Administered Once a Day (10 mg OD) Versus Twice a Day (5 mg BID) in Healthy Male and Female Volunteers ClinicalTrials.gov · COMPLETED, 2010
A Randomized, Double-Blind, Placebo Controlled, Parallel Group Study of the Efficacy and Safety of WELCHOL as Add-on to Pioglitazone Therapy for Type 2 Diabetes Mellitus (T2DM) ClinicalTrials.gov · COMPLETED, 2012
A Phase 1B, Randomized, Double-Blind, Placebo-Controlled Trial To Assess The Efficacy And Safety Of 4-Week Administration Of Multiple Oral Doses Of PF-04620110 In Type 2 Diabetes Mellitus Subjects With Insufficient Glycemic Control On Metformin ClinicalTrials.gov · COMPLETED, 2011
Glycemic Control in Children and Adolescents With Double Diabetes: Trial of Optimized Insulin-Metformin Regimen ClinicalTrials.gov · COMPLETED, 2014
A Comparison of Exenatide and Insulin Glargine on Glycemic Variability in T2DM Patients Inadequately Controlled With Metformin Monotherapy ClinicalTrials.gov · COMPLETED, 2016
Open-label, Randomized, Two-period Comparative Pharmacokinetics and Bioequivalence Study of Empagliflozin + Metformin Hydrochloride 5 mg/1000 mg Film-coated Tablets (Gedeon Richter Plc., Hungary) Versus Synjardy 5 mg/1000 mg Film-coated Tablets (Boehringer Ingelheim International GmbH, Germany) in Healthy Volunteers Under Fed Conditions ClinicalTrials.gov · COMPLETED, 2025
A Phase IIb, Randomized, Double-blind, Placebo-controlled, Parallel Group, Safety and Efficacy Study of BI 10773 (10 mg and 25 mg) Administered Orally, Once Daily Over 78 Weeks in Type 2 Diabetic Patients Receiving Treatment With Basal Insulin (Glargine, Detemir, or NPH Insulin Only) With or Without Concomitant Metformin and/or Sulfonylurea Therapy and Insufficient Glycemic Control ClinicalTrials.gov · COMPLETED
Effect of Empagliflozin on Liver Fat Content in Patients With Type 2 Diabetes: A 12-week Randomized Clinical Study ClinicalTrials.gov · COMPLETED, 2017
ADIponectin and ADMA Level in Type-2 Diabetes Patients After 12 Weeks of Treatment With GlimepiRide And Metformin Fixed Dose Combination (Amaryl-M) ClinicalTrials.gov · COMPLETED, 2012
Metformin Effect as a Chemotherapeutic Adjuvant on Level of IGF in Non-diabetic Breast Cancer Patients ClinicalTrials.gov · COMPLETED, 2021
Action to Control Cardiovascular Risk in Diabetes (ACCORD) ClinicalTrials.gov · COMPLETED, 2012
A Phase IIb, Randomised, Parallel, Double-Blind Placebo-Controlled and Open-Label Active Comparator Study to Evaluate the Efficacy and Safety of MEDI0382 in the Treatment of Overweight and Obese Subjects With Type 2 Diabetes Mellitus ClinicalTrials.gov · COMPLETED, 2019
A Trial Comparing NNC0148-0287 C (Insulin 287) Versus Insulin Glargine U100, Both in Combination With Metformin, With or Without DPP4 Inhibitors and With or Without SGLT2 Inhibitors, in Basal Insulin Treated Subjects With Type 2 Diabetes Mellitus ClinicalTrials.gov · COMPLETED, 2020
An Open-label Study to Assess the Safety and Tolerability of MK-0431D for the Treatment of Patients With Type 2 Diabetes Mellitus (T2DM) With Inadequate Glycemic Control on Metformin Monotherapy ClinicalTrials.gov · COMPLETED, 2013
A 16 Week Randomised, Open-labelled, Four-armed, Treat-to-target, Parallel-group Trial Comparing SIBA D Once Daily, SIBA E Once Daily, SIBA D Monday, Wednesday and Friday and Insulin Glargine Once Daily, All in Combination With Metformin in Subjects With Type 2 Diabetes Failing on OAD Treatment ClinicalTrials.gov · COMPLETED, 2008
Is There a Pharmacokinetic Interaction Between St John's Wort and Metformin? ClinicalTrials.gov · COMPLETED, 2014