Browse studies, page 1063

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• Single-Dose Fasting In Vivo Bioequivalence Study of Metformin Hydrochloride ER Tablets (500 mg; Mylan) and Glucophage® XR Tablets (500 mg; Bristol-Myers Squibb) in Healthy Volunteers ClinicalTrials.gov · COMPLETED, 2004
• Effect of Pioglitazone Compared With Metformin on Endothelial Microparticles in Type 2 Diabetes. A Randomized Trial ClinicalTrials.gov · COMPLETED, 2015
• A Phase 3, Randomized, Double-Blind, Placebo-Controlled, 26-Week Multicenter Study to Evaluate the Efficacy and Safety of Ertugliflozin in Asian Subjects With Type 2 Diabetes Mellitus and Inadequate Glycemic Control on Metformin Monotherapy (VERTIS-ASIA) ClinicalTrials.gov · COMPLETED, 2017
• Comparison of the Effects of Metformin and Pioglitazone on Liver Enzymes ClinicalTrials.gov · COMPLETED, 2022
• LIRA-ADD2SGLT2i - Liraglutide Versus Placebo as add-on to SGLT2 Inhibitors ClinicalTrials.gov · COMPLETED, 2018
• Comparison of Efficacy of Metformin Gel 30% vs Triple Combination Cream (Hydroquinone 4%, Flucinolone Acetonide 0.01%, Tretinoin 0.025%) in Treatment of Melasma in Tertiary Care Hospital Karachi ClinicalTrials.gov · COMPLETED, 2025
• A Single-center,Double-blind,Randomised,Placebo-controlled,Parallel-group Study to Assess the Effect of 24 Weeks of Treatment With Vildagliptin on Insulin Sensitivity and Its Underlying Mechanism in Patients With T2DM Treated With Metformin ClinicalTrials.gov · COMPLETED, 2013
• A Phase 1, Open-Label, Randomized, Cross-Over Study To Estimate The Pharmacokinetics Of PD 0332334 And Metformin When Administered Concurrently In Healthy Subjects ClinicalTrials.gov · TERMINATED, 2009
• A Phase 3, Randomized, Double-blinded Study to Evaluate the Efficacy and Safety of HRS-7535 Compared With Dapagliflozin in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin (OUTSTAND-2) ClinicalTrials.gov · COMPLETED, 2026
• The Pharmacokinetic Interaction Between Metformin and Nizatidine in Healthy Volunteers ClinicalTrials.gov · COMPLETED, 2013
• Pilot Study Evaluating the Efficacy and Safety of Metformin in Melanoma ClinicalTrials.gov · COMPLETED, 2015
• Randomized, Double-Blind, Efficacy and Safety, Controlled Study, Between DMMET-01 and Metformin on Improvement of Metabolic Control in Naive Type 2 Diabetics Patients ClinicalTrials.gov · COMPLETED
• A Phase 3 Study to Assess the Efficacy and Safety of ASP1941 in Combination With Metformin in Patients With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Metformin Alone ClinicalTrials.gov · COMPLETED, 2011
• Effect of GLP-1 Receptors Agonist Lixisenatide on Postprandial Lipid Profile in Obese Type 2 Diabetic Patients ClinicalTrials.gov · TERMINATED, 2015
• The Effects of Metformin Therapy on Changes in Metabolic, Vitamin B12, Iron Status, Erythropoietin, and Hematological Parameters Among Women With Polycystic Ovary Syndrome: A Double-Blind Randomized Controlled Trial ClinicalTrials.gov · COMPLETED, 2026
• The Efficacy of Metformin Produced by Pars Mino Co in Comparison With Canadian Apotex Co ClinicalTrials.gov · COMPLETED, 2009
• A 24-week International, Multicenter, Randomized, Open-Label, Active-Controlled, Parallel Group, Phase 3b Trial With a 28-week Extension to Evaluate the Efficacy and Safety of Saxagliptin Co-administered With Dapagliflozin Compared to Insulin Glargine in Subjects With Type 2 Diabetes Who Have Inadequate Glycemic Control on Metformin With or Without Sulfonylurea Therapy ClinicalTrials.gov · COMPLETED, 2017
• A Double-blind, Placebo Controlled Trial of Metformin Treatment in Progressive Multiple Sclerosis ClinicalTrials.gov · COMPLETED, 2025
• A Phase 1b, Randomized, Placebo-Controlled Study to Assess the Safety and Pharmacokinetics of Double-Blind S-707106 Alone and in Combination With Open-Label Metformin in Patients With Type 2 Diabetes Mellitus ClinicalTrials.gov · COMPLETED, 2010
• A Pilot Study of Intensive Insulin Regimen as a Primary Treatment of New Onset of Type 2 DM ClinicalTrials.gov · COMPLETED, 2014
• A Multicenter, Register-based, Randomized, Controlled Trial Comparing Dapagliflozin With Metformin Treatment in Early Stage Type 2 Diabetes Patients by Assessing Mortality and Macro- and Microvascular Complications ClinicalTrials.gov · COMPLETED, 2026
• Clinical Evaluation of Fenugreek Seed Extract, a Nutraceutical in Patients With Type- 2 Diabetes: An Add-On Study ClinicalTrials.gov · COMPLETED, 2018
• The Effects of Insulin Detemir and Gliclazide-MR Treatments in Addition to Life-style Modification and Metformin Therapy on Endothelial Functions in Patients With Type 2 Diabetes : An Open-labelled Randomized Prospective Study ClinicalTrials.gov · COMPLETED, 2012
• Effect of Use of Calcium Hydroxide and Metformin as Intracanal Dressings in Healing of Apical Periodontitis in Mature Permanent Mandibular Molars: A Randomized Clinical Trial ClinicalTrials.gov · COMPLETED, 2025
• Independent and Additive Effects Of Micronutrients With Metformin In Patients With PCOS:A Double Blind Randomized Placebo Controlled Trial ClinicalTrials.gov · COMPLETED, 2024
• A Randomized, Double-Blind Trial Assessing the Efficacy and Safety of Low and Standard Doses of Fenofibrate in Combination With Metformin on the Lipid Profile in Patients With Type 2 Diabetes and Dyslipidemia ClinicalTrials.gov · COMPLETED
• A 4-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 3 Trial To Evaluate The Efficacy And Safety Of Saxagliptin In Comparison To Placebo As Add On Treatment To Metformin XR In Subjects With Type 2 Diabetes Who Have Inadequate Glycemic Control With Diet And Exercise And A Stable Dose Of Metformin ≥1500 mg/Day ClinicalTrials.gov · COMPLETED, 2009
• A Mobile Smartphone Application to Promote a Healthy Diet and Physical Activity Among Pregnant Women With Gestational Diabetes Mellitus - RCT ClinicalTrials.gov · COMPLETED, 2017
• A Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Sequential Panel Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of MK0941 After Multiple Daily Administration of MK0941 Before Each Meal (q.a.c.) in Subjects With Type 2 Diabetes ClinicalTrials.gov · COMPLETED, 2008
• A Phase III Randomised, Double-blind, Double-dummy, Parallel Group Study to Compare the Efficacy and Safety of Twice Daily Administration of the Fix Dose Combination of Linagliptin 2.5 mg + Metformin 500 mg, or of Linagliptin 2.5 mg + Metformin 1000 mg, With the Individual Components of Metformin (500 mg or 1000 mg, Twice Daily), and Linagliptin (5.0 mg, Once Daily) Over 24 Weeks in Treatment naïve Type 2 Diabetic Patients With Insufficient Glycaemic Control ClinicalTrials.gov · COMPLETED, 2014
• A Phase 3, Multicenter, Double-Blind, Randomized, Parallel-group, Placebo-Controlled Study to Assess the Efficacy and Safety of ASP1941 in Subjects With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control on Metformin and Sitagliptin ClinicalTrials.gov · COMPLETED, 2017
• Metformin, Exenatide, and Glargine Insulin in Combination for Treatment of Patients With Type 2 Diabetes ClinicalTrials.gov · COMPLETED, 2010
• A Phase 1, Open-Label Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of Metformin ClinicalTrials.gov · COMPLETED, 2013
• Efficacy of Lifestyle Interventions and Metformin for the Treatment of Antipsychotic-Induced Weight Gain: a Randomized Double-Blind Placebo- Controlled Comparison ClinicalTrials.gov · COMPLETED, 2006
• A Randomized, Placebo-Controlled Dose-Escalation Study to Assess the Safety and Tolerability of a Single Intravenous Infusion of Allogeneic Mesenchymal Precursor Cells (MPCs) in Patients With Type 2 Diabetes Sub-optimally Controlled on Metformin ClinicalTrials.gov · COMPLETED, 2015
• Effect of Metformin Intervention on Patients With Polycystic Ovary Syndrome ClinicalTrials.gov · COMPLETED, 2023
• Safety and Tolerability of Trospium Chloride Metformin Hydrochloride in Healthy Subjects ClinicalTrials.gov · COMPLETED, 2009
• A Multicenter, Double-blind, Randomized Parallel-group, Study to Demonstrate the Effect of 24 Weeks Treatment With Vildagliptin 100 mg qd as add-on to Metformin 500 mg Bid Compared to Metformin 1000 mg Bid in Patients With Type 2 Diabetes Inadequately Controlled on Metformin 500 mg Bid Monotherapy ClinicalTrials.gov · COMPLETED
• A Two-Cohort, Single- and Repeat Dose Study to Examine the Pharmacokinetics, Tolerability, and Safety of Ready to Use Exenatide Once Weekly in Healthy Subjects and in Subjects With Type 2 Diabetes Mellitus ClinicalTrials.gov · COMPLETED, 2009
• A Multicenter, Randomized, Active-controlled, Parallel Group, Open-label, Exploratory Study to Evaluate the Efficacy on Glucose Variability(MAGE, Glucose SD) and Safety of Initial Combination Therapy of Gemigliptin 50mg q.d., Versus Sitagliptin 100mg q.d., or Glimepiride 2mg q.d. With Metformin 500-1,000mg q.d. in Patients With Type 2 Diabetes ClinicalTrials.gov · COMPLETED, 2014
• Single-Dose Food In Vivo Bioequivalence Study of Glipizide and Metformin HCl Tablets (5 mg/500 mg; Mylan) to Metaglip® Tablets (5 mg/500 mg; Bristol-Myers Squibb) in Healthy Volunteers ClinicalTrials.gov · COMPLETED, 2005
• Phase Ib Study of Metformin and Chloroquine in IDH1/2-mutated Patients With Glioma, Intrahepatic Cholangiocarcinoma or Chondrosarcoma ClinicalTrials.gov · COMPLETED, 2019
• A Two Part Bioequivalence Study to Compare Two Fixed Dose Combination Tablets of Dapagliflozin/Metformin XR 5/500 mg (Part 1) and 10/1000 mg (Part 2) Manufactured at Two Different Plants in Healthy Subjects Under Fasting and Fed Conditions ClinicalTrials.gov · COMPLETED, 2016
• An Open-label, Two-arm Crossover Study to Investigate the Effect of BMS-986165 on the Pharmacokinetics of Metformin in Healthy Volunteers ClinicalTrials.gov · COMPLETED, 2021
• A Randomised, Open, Placebo Controlled, Two-way Crossover Phase I Study in Type 2 Diabetes Mellitus Patients Treated With Metformin to Evaluate the Effect of Gemfibrozil on the Pharmacokinetics and Pharmacodynamics of a Single Dose of AZD1656 ClinicalTrials.gov · COMPLETED, 2010
• Metformin in Association to Chemoradiotherapy for the Neoadjuvant Treatment of Locally Advanced Rectal Cancer: a Randomized, Placebo-controlled Phase II Study ClinicalTrials.gov · TERMINATED, 2016
• An Adaptive, Randomized, doublE-blind, Placebo-controlled, Prospective, Pharmacological interVention Study In Participants With Long COVID-19 Syndrome: REVIVE-TOGETHER Trial ClinicalTrials.gov · COMPLETED, 2025
• A Randomized, Placebo-controlled, Three-Way Crossover Study to Evaluate the Effect of SCH 497079 on Metabolic Parameters and to Determine the Influence of Race/Ethnic Origin on Therapeutic Response ClinicalTrials.gov · COMPLETED, 2008
• A Randomized, Open-label, Single Dose, Crossover Study to Compare the Pharmacokinetic Characteristics of the Co-administration of Metformin SR and Rosuvastatin and JLP-1310 (1000/10mg) in Healthy Male Volunteers ClinicalTrials.gov · COMPLETED, 2019
• A Phase I, Open-label, Single-center Study to Assess the Pharmacokinetics of Metformin, an OCT2 Substrate, in Healthy Subjects When Administered Alone and in Combination With a Single Oral Dose of Vandetanib (CAPRELSA) 800 mg ClinicalTrials.gov · COMPLETED, 2012
• Effects of Dapagliflozin Compared With Glimepiride on Body Composition in Patients With Type 2 Diabetes Inadequately Controlled With Metformin ClinicalTrials.gov · COMPLETED, 2018
• A Phase IIa Trial of Metformin for Colorectal Cancer Risk Reduction among Individuals with History of Colorectal Adenomas and Elevated Body Mass Index Cancer prevention research (Philadelphia, Pa.), 2020
• Metformin targets mitochondrial complex I to lower blood glucose levels Science advances, 2024
• Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin Cell metabolism, 2016
• Aspects of antihyperglycemic oral bitherapy in 76 cases of non insulindependent diabetes in Dakar Sante (Montrouge, France), 2002
• Metformin inhibits nerve growth factor-induced sympathetic neuron differentiation through p35/CDK5 inhibition American journal of physiology. Cell physiology, 2024
• Probucol prevents blood-brain barrier dysfunction and cognitive decline in mice maintained on pro-diabetic diet Diabetes & vascular disease research, 2019
• Effect of metformin therapy on circulating amino acids in a randomized trial: the CAMERA study Diabetic medicine : a journal of the British Diabetic Association, 2016
• Metformin inhibits NF-κB p65/RelA-NLRP3 inflammasome-IL-1β axis, attenuates lipid droplet accumulation, and reprograms CD14/CD16 expression in monocytes exposed to colorectal tumor-conditioned medium International immunopharmacology, 2025
• Environmental Enrichment and Metformin Combination Improves Cognitive Function through BDNF and HPA Axis in Chronically Stressed Rats Current Alzheimer research, 2025
• Metformin: A Candidate Drug for Renal Diseases International journal of molecular sciences, 2018
• Activation of AMP-activated Protein Kinase by Metformin Induces Protein Acetylation in Prostate and Ovarian Cancer Cells The Journal of biological chemistry, 2016
• Metanalyses on metformin's role in pancreatic cancer suffer from severe bias and low data quality - An umbrella review Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2023
• Metformin's Therapeutic Efficacy in the Treatment of Diabetes Does Not Involve Inhibition of Mitochondrial Glycerol Phosphate Dehydrogenase Diabetes, 2021
• Metabolic impact of current therapeutic strategies in Polycystic Ovary Syndrome: a preliminary study Molecular biology reports, 2023
• Unveiling the impacts of metformin on hepatocellular carcinoma: A bioinformatic exploration in cell lines Narra J, 2024
• Impact of metformin on gene expression in Burmese loach (Lepidocephalichthys berdmorei) from Manipur, India The Science of the total environment, 2025
• Metformin enhances methylene blue-mediated photodynamic therapy in oral squamous cell carcinoma Journal of the Egyptian National Cancer Institute, 2026
• Caveolin-1 is essential for metformin inhibitory effect on IGF1 action in non-small-cell lung cancer cells FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2012
• Metformin inhibits growth and decreases resistance to anoikis in medullary thyroid cancer cells Endocrine-related cancer, 2012
• Case report: a co-occurring case of severe Mycoplasma pneumoniae pneumonia and Anti-IgLON5 antibody-associated encephalitis in a pediatric patient Frontiers in Medicine, 2024
• Systemic Sclerosis 2011 International Journal of Rheumatology, 2012
• Feasibility of the use of phosphodiesterase type 5 inhibitors in a pharmacologic prevention program for recurrent priapism Journal of Sexual Medicine, 2006
• P026 Chronic chilblain like lesions associated with the COVID-19 pandemic Rheumatology, 2023
• (432) Efficacy of Low-Intensity Shockwave Therapy on Hard Flaccid Syndrome: Initial Report of Three Cases Journal of Sexual Medicine, 2023
• AB1304 chronic chilblain-like lesions associated with the COVID-19 pandemic Annals of the Rheumatic Diseases, 2023
• Phosphodiesterase-5 inhibitors for the treatment of Raynaud's: a novel indication Expert Opinion on Investigational Drugs, 2009
• (377) Optimization of the Medical Protocol for the Treatment of Peyronie's Disease Journal of Sexual Medicine, 2023
• Olfactory and Gustatory Dysfunction as an Early Identifier of COVID-19 in Adults and Children: An International Multicenter Study Otolaryngology Head & Neck Surgery, 2020
• Real-world experience using combination therapy with riociguat and risk assessment using REVEAL Lite 2.0 in patients with pulmonary arterial hypertension Pulmonary Circulation, 2020
• Novel association of chilblains with inflammatory arthritis- series of three cases and review of literature Rheumatology International, 2025
• Ischemic Optic Neuropathies: a Case Series Study (P1.137) Neurology, 2018
• (423) A Case Series of Successful Off-label Use of Flibanserin Journal of Sexual Medicine, 2023
• Redo pelvic fracture urethral injury repair: The case for tadalafil Turkish journal of urology, 2021
• Treatment of severe lipophilic intoxications with intravenous lipid emulsion: a case series (2011-2014) Veterinary medicine, 2017
• Tadalafil to improve cutaneous flap perfusion in smokers: A case series and literature review JAAD Case Reports, 2021
• Phosphodiesterase 5 inhibitors lower both portal and pulmonary pressure in portopulmonary hypertension: a case report Journal of Medical Case Reports, 2007
• The Development of Cerebral Venous Thrombosis after Tadalafil Ingestion in a Patient with Antiphospholipid Syndrome Internal medicine, 2017
• A Case of Acute Pulmonary Thromboembolism after Taking Tadalafil Tuberculosis and Respiratory Diseases, 2012
• P113 A challenging case of mixed connective tissue disease with pulmonary hypertension Rheumatology Advances in Practice, 2025
• (570) Unveiling Multifactorial Erectile Dysfunction in Klinefelter Syndrome: A Clinical Case Journal of Sexual Medicine, 2026
• Results of tadalafil treatment in patients following an open nerve-sparing radical prostatectomy Archivio Italiano di Urologia e Andrologia, 2016
• Early Effects of Oral Pulmonary Vasodilators in an Elderly Patient with Critical Thromboembolic Pulmonary Hypertension: A Case Report Journal of Nippon Medical School = Nippon Ika Daigaku zasshi, 2015
• Penile allotransplantation for penis amputation following ritual circumcision: a case report with 24 months of follow-up The Lancet, 2017
• MP53-13 efficacy of tadalafil for treating chronic prostatitis/chronic pelvic pain syndrome in patients without erectile dysfunction Journal of Urology, 2019
• GW26-e0266 Safety and effectiveness of Tadalafil on PAH from a post-marketing surveillance (Investigation on all patients in Japan, interim data) 2015
• Impact of Switch to Non-Prescription Status on the Safety Profile of Sildenafil and Tadalafil: Assessment of Pharmacovigilance Databases Indian Journal of Pharmaceutical Sciences, 2024
• Medical treatment for an adult patient with eisenmenger syndrome. A case report International Heart Journal, 2015
• Mimicry of surgical site infection – Case report International journal of surgery case reports, 2020
• Perioperative management with phosphodiesterase type 5 inhibitor and prostaglandin E1 for moderate portopulmonary hypertension following adult-to-adult living-donor liver transplantation: a case report Surgery Case Reports, 2018