Phase II Combination Therapy Selection Trial in Amyotrophic Lateral Sclerosis
Abstract
The objective of this study is to compare two combinations of drugs, minocycline and creatine or celecoxib and creatine, in a phase II trial designed to determine which combination is more effective for ALS.
Conditions: Amyotrophic Lateral Sclerosis.
Primary outcome: ALS Functional Rating Scale Revised (ALSFRS-R) completed monthly during trial..
Enrollment: 86 participants.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 86 participants or records.
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