Dolutegravir in Pregnant HIV Mothers and Their Neonates
Abstract
To evaluate dolutegravir (DTG) efficacy in women who present with untreated HIV in late pregnancy.
An open-label, multi-centre randomised controlled trial of DTG vs efavirenz-based regimens for women commencing cART in late pregnancy. HIV positive pregnant women presenting with untreated HIV infection in late (≥28 weeks gestation) pregnancy will be randomised 1:1 to receive DTG (50mg once daily) + 2 nucleoside reverse transcriptase inhibitors (NRTIs) or EFV + 2 NRTIs (SoC)
Conditions: HIV-1-infection, Pregnancy Related.
Primary outcome: HIV Viral Load at Delivery.
Enrollment: 268 participants.
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 268 participants or records.
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