Serum Creatine Phosphokinase
Abstract
Introduction Since the report of Sibley and Lehninger1on the increase of serum aldolase activity in 2 patients with progressive muscular dystrophy in 1949, which was later confirmed by Schapira, Dreyfus, and Schapira2and many other workers,3-8the activity of enzymes in serum, especially that of aldolase, has been considered to be the most reliable biochemical test for the diagnosis of progressive muscular dystrophy. Furthermore, a number of different enzymes, including glutamic oxalacetic transaminase9and lactic dehydrogenase,8have been reported to be increased in the sera of patients with this disease. Recently we added creatine phosphokinase to the list of such enzymes.10The present communication is concerned with the determination of creatine phosphokinase and aldolase activities in the sera of patients with progressive muscular dystrophy and neuromuscular diseases. Material and Method Ninety cases of progressive muscular dystrophy and neuromuscular diseases, 15 cases of liver
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