Rhabdomyolysis Secondary to Reactivated Herpes Simplex Virus Type 1 Coinfected with Klebsiella pneumoniae in an Elderly Patient: A Case Report
Abstract
Abstract Rhabdomyolysis is a common syndrome involving the breakdown of muscle tissue. It is a serious condition that may be complicated by acute kidney injury and can even be life-threatening; however, it is highly prone to being missed. To date, no comprehensive domestic or international case reports have described rhabdomyolysis triggered by coinfection with herpes simplex virus type 1 (HSV-1) and Klebsiella pneumoniae. This is the first documented case of occult rhabdomyolysis driven by latent HSV-1 reactivation (without concomitant encephalitis or seizures) and concurrent Klebsiella pneumoniae infection. For bedridden elderly patients with dementia, routine testing for creatine kinase (CK) and myoglobin is recommended to facilitate early diagnosis of rhabdomyolysis, prevent acute kidney injury and multi-organ dysfunction. After targeted anti-infection therapy, sufficient fluid resuscitation combined with nutritional and immune supportive care, the patient’s creatine kinase and inflammatory biomarkers normalized, and clinical status improved gradually. We hypothesize that the rhabdomyolysis was caused by a herpes simplex virus infection complicated by a Klebsiella pneumoniae coinfection. This case represents the first reported instance of cryptic rhabdomyolysis induced by latent HSV-1 reactivation (without encephalitis or seizures) combined with Klebsiella pneumoniae infection. Clinicians should routinely test CK and myoglobin levels in elderly bedridden dementia…
How strong is the evidence?
Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
Read the paper
Related studies
- Biportal endoscopic versus microscopic lumbar decompressive laminectomy in patients with spinal stenosis: A randomized controlled trial
- A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial
- Supplement-based nutritional strategies to tackle frailty: A multifactorial, double-blind, randomized placebo-controlled trial
- A randomized, double-blind, placebo-controlled, proof-of-concept trial of creatine monohydrate as adjunctive treatment for bipolar depression
- Creatine supplementation (3 g/day) and bone health in older women: a 2-year, randomized, placebo-controlled trial
- A Multi-Ingredient Nutritional Supplement in Combination With Resistance Exercise and High-Intensity Interval Training Improves Cognitive Function and Increases N-3 Index in Healthy Older Men: A Randomized Controlled Trial
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.