Vitamin C Attenuates Trichloroacetic Acid-Induced Cardiac Injury and Fibrotic Remodeling in Rats: Biochemical and Histopathological Evidence
Abstract
Abstract Trichloroacetic acid (TCA), a widely used chemical in industrial, educational, and research settings, has been associated with various toxic effects, including inflammation-mediated tissue injury. This study investigated the protective effects of vitamin C against TCA-induced cardiac injury in rats. Twenty male Wistar rats were randomly assigned to four groups (n = 5/group): control, TCA, vitamin C, and TCA plus vitamin C. Treatments were administered orally by gavage for 21 consecutive days. At the end of the experiment, serum interleukin-1β (IL-1β) levels and creatine phosphokinase (CPK) activity were measured, and cardiac tissues were evaluated histopathologically for structural alterations and myocardial fibrosis. TCA administration significantly increased serum IL-1β concentrations and CPK activity compared with the control group (P
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