Association of the hsCRP–Glycemia Index with Coronary Artery Occlusion in Diabetic Patients with STEMI
Abstract
Background: : The coexistence of elevated hs-CRP levels and diabetes mellitus may play a significant role in plaque destabilization, favoring plaque rupture and thrombosis, and consequently increasing the risk of coronary artery occlusion and acute coronary syndrome.
Purpose:: This study aimed to assess the CRP-glycemia index as potential predictors of of coronary artery occlusion in diabetic patients with acute coronary syndrome.
Methods:: The study included 131 consecutive patients presenting with ST-segment elevation myocardial infarction (STEMI) within 12 hours of symptom onset who underwent percutaneous coronary intervention (PCI). At admission, laboratory assessments were performed, including creatine kinase (CK), CK-MB, troponin I, high-sensitivity C-reactive protein (hs-CRP), glucose, blood urea nitrogen (BUN), creatinine, cholesterol, and standard biochemical parameters. The CRP–glycemia index (CRPGI) was calculated using the formula: CRPGI = CRP (mg/L) × glucose (mmol/L). Based on the presence of coronary artery occlusion, patients were stratified into two groups: those with acute coronary syndrome and total coronary artery occlusion (ACS/CA-total occlusion (TO), Group 1) and those with ACS and non-total coronary artery occlusion (ACS/CA-non-total occlusion (nTO), Group 2).
Results:: Of the 131 diabetic patients with STEMI treated with PCI, 77 (58.77) had ACS/CA-TO (Group 1), while 54 (41.22%) had ACS/CA-nTO (Group 2) (Table 1). CRPGI differed significantly between…
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