Advancing Age Is Not Associated With Greater Exercise-Induced Muscle Damage: A Systematic Review, Meta-Analysis, and Meta-Regression
Abstract
OBJECTIVE
The aim of this paper was to undertake a Preferred Reporting Items for Systematic Reviews and Meta-Analysis-accordant meta-analysis comparing exercise-induced muscle damage (EIMD) in older and younger adults.
METHODS
Google Scholar, PubMed, and SPORTDiscus were searched in June 2023 for the terms "ageing" OR "age" OR "middle-aged" OR "old" OR "older" OR "elderly" OR "masters" OR "veteran" AND "muscle damage" OR "exercise-induced muscle damage" OR "exercise-induced muscle injury" OR "contraction-induced injury" OR "muscle soreness" OR "delayed onset muscle soreness" OR "creatine kinase." From 1,092 originally identified titles, 36 studies were included which had an exercise component comparing a younger against an older group. The outcome variables of EIMD were muscle function, muscle soreness, and creatine kinase. A meta-analysis was conducted on change to EIMD after exercise in older versus younger adults using standardized mean difference (SMD) and an inverse-variance random effects model.
RESULTS
Change after 24 and 72 hr, and peak change, in muscle function was not different between old and young (SMD range = -0.16 to -0.35). Muscle soreness was greater in younger than older adults for all comparisons (SMD range = -0.34 to -0.62). Creatine kinase was greater in younger than older adults at 24 hr (SMD = -0.32), as was peak change (SMD = -0.32). A relationship between sex and peak muscle function change was evident for males (SMD = -0.45), but not females (SMD =…
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