Evaluating the Therapeutic Impact of L-Carnitine on Postoperative Left Ventricular Ejection Fraction in Patients Undergoing Coronary Artery Bypass Grafting: A Meta-Analysis
Abstract
Background: L-Carnitine (LC) plays a crucial role in transporting long-chain fatty acids into mitochondria for oxidation, which is particularly important for the heart and skeletal muscles. Additionally, it acts as an antioxidant and anti-inflammatory agent, helping to protect tissues from damage caused by reactive oxygen species (ROS). This study aims to evaluate the effect of LC on postoperative left ventricular ejection fraction (LVEF) in patients undergoing coronary artery bypass grafting (CABG).
Methods: This systematic review adhered to PRISMA guidelines and searched Google Scholar, PubMed, and ScienceDirect for randomized controlled trials (RCTs) comparing L-Carnitine to placebo in CABG patients. We focused on outcomes related to left ventricular ejection fraction (LVEF) and serum creatine kinase-MB (CK-MB) levels. Data were analyzed using a random-effects model, with results reported as weighted mean differences (WMD) and 95% confidence intervals (CI), considering statistical significance at p < 0.05.
Results: The analysis included five RCTs involving 365 CABG patients, with LC doses ranging from 2 to 6 g per day, administered from one month before to 180 days after surgery. The results showed that LC significantly improved LVEF (Weighted Mean Difference [WMD]: 3.22%, 95% Confidence Interval [CI]: 0.28 to 6.16, P = 0.0001). Additionally, LC treatment resulted in a reduction of serum creatine kinase-MB (WMD: -12.75, 95% CI: -22.46 to -3.05, P = 0.01). However, there…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 365 participants or records.
Read the paper
Related studies
- Biportal endoscopic versus microscopic lumbar decompressive laminectomy in patients with spinal stenosis: A randomized controlled trial
- A whey protein-based multi-ingredient nutritional supplement stimulates gains in lean body mass and strength in healthy older men: A randomized controlled trial
- Supplement-based nutritional strategies to tackle frailty: A multifactorial, double-blind, randomized placebo-controlled trial
- A randomized, double-blind, placebo-controlled, proof-of-concept trial of creatine monohydrate as adjunctive treatment for bipolar depression
- Creatine supplementation (3 g/day) and bone health in older women: a 2-year, randomized, placebo-controlled trial
- A Multi-Ingredient Nutritional Supplement in Combination With Resistance Exercise and High-Intensity Interval Training Improves Cognitive Function and Increases N-3 Index in Healthy Older Men: A Randomized Controlled Trial
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.