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Effects of Combined Versus Single Supplementation of Creatine, Beta-Alanine, and L-Citrulline During Short Sprint Interval Training on Basketball Players' Performance: A Double-Blind Randomized Placebo-Controlled Trial

Menghao Li, Mohsen Sheykhlouvand

International Journal of Sports Physiology and Performance, 2025

8 participants · 14 citations

Abstract

PURPOSE

Athletes often use sport supplements to improve their physical and physiological performance. This randomized, double-blind, placebo (PL) -controlled study aimed to investigate the effects of combined versus single supplementation of creatine (Cr), beta-alanine (BA), and L-citrulline (L-Cit) during short sprint interval training (SSIT) on basketball players' physical and physiological performance over a period of 28 days.

METHODS

Forty-eight basketball players were equally assigned to 6 groups of Cr (0.1 g/kg of Cr monohydrate daily), BA (4.8 g daily), L-Cit (6 g daily), combined supplementation, PL, and an active control group, and each group consisted of 8 participants. The training groups participated in SSIT (3 sets of 10 repetitions of 5-s all-out runs) sessions 3 times a week for 4 weeks. Physical (vertical jump, 20-m sprint, Illinois change of direction) and physiological (Wingate anaerobic power and cardiorespiratory fitness test) performance were evaluated before and after the training period.

RESULTS

All training groups (Cr, BA, L-Cit, combined, and PL) showed significant improvements in physical and physiological performance over the 4-week intervention (P < .05). Interestingly, the supplement groups displayed significantly (P = .001) greater changes than the PL group, indicating better outcomes in performance adaptations. However, significant differences in performance variables were observed among the supplement groups.

CONCLUSION

Our findings indicate…

How strong is the evidence?

Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 8 participants or records.

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