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Comparison of Effect of Levocetirizine or Montelukast Alone and in Combination on Symptoms of Allergic Rhinitis

Andhale S, Goel HC, Nayak S

The Indian journal of chest diseases & allied sciences, 2016

8 citations

Abstract

Objective. To determine the effect of levocetirizine, montelukast and the combination of both the drugs on symptoms of allergic rhinitis. Methods. Seventy-five patients with allergic rhinitis were randomly studied prospectively for a period of two weeks divided into three groups receiving either levocetrizine or montelukast or combination of both. The outcomes were measured by a visual analogue score for nasal and eye symptom during day-time and night-time. Results. All the three regimens were equally effective in improving the day-time symptoms, like sneezing and rhinorrhea. There was also no difference in the control of night-time and eye symptoms among the regimens. Conclusions. Montelukast, levocetirizine and their combination is equally effective in controlling symptoms, of allergic rhinitis. Thus, use of montelukast alone would be cost-effective and do avoid adverse effects of levocetirizine in combination therapy

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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.

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