Evidence Hub

Levocetirizine Withdrawal anxiety: A Case Report

K. Pun, Roshni Thapa, Sanjeev Kumar Mishra

Journal of Psychiatrists Association of Nepal, 2025

Abstract

Levocetirizine, an antihistamine, is commonly prescribed for allergic conditions. The drug is often sold on an over the counter basis without any consideration of potential side effects or susceptibility to abuse. Here we present one such case who had withdrawal anxiety features after taking levocetirizine for a prolonged period which resolved after gradual tapering of levocetirizine under clonazepam coverage. Though second generation antihistamines do not cross the blood brain barrier and are believed to have no neurological effects, this case highlights the possibility that this may not be entirely true.

How strong is the evidence?

Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

Read the paper

Related studies

Go deeper in Evidence Hub

Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.

Open this study Sign up free