Comparative Evaluation of Efficacy and Safety of Intranasal Corticosteroids Versus Oral Levocetirizine in Patients with Allergic Rhinitis Attending a Tertiary Care Centre in North India
Abstract
Background: Allergic rhinitis (AR) is a chronic inflammatory disorder of the nasal mucosa mediated by immunoglobulin E (IgE) after exposure to environmental allergens. It is characterized by sneezing, rhinorrhea, nasal obstruction, itching, and frequently associated ocular symptoms. Allergic rhinitis significantly impairs quality of life, sleep, school performance, and workplace productivity. Pharmacological management primarily includes intranasal corticosteroids and second-generation H1 antihistamines; however, their comparative effectiveness remains an area of clinical interest. Aim: To compare the efficacy and safety of intranasal corticosteroids and oral levocetirizine in patients with allergic rhinitis. Materials and Methods: A hospital-based observational comparative study was conducted in the Departments of Pharmacology and Otorhinolaryngology of Muzaffarnagar Medical College and Hospital, Uttar Pradesh. A total of 150 adult patients diagnosed with allergic rhinitis were enrolled. Patients were divided into two groups: Group A received intranasal corticosteroids and Group B received oral levocetirizine 5 mg. Clinical efficacy was assessed using Total Nasal Symptom Score (TNSS), Total Ocular Symptom Score (TOSS), and Total Symptom Score (TSS) at 1 week, 1 month, and 3 months. Adverse drug reactions were recorded during follow-up. Statistical analysis was performed using SPSS version 29, and p <0.001 was considered statistically significant. Results: The mean age of…
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