Letter in response to “Effectiveness and safety of levocetirizine 10 mg versus a combination of levocetirizine 5 mg and montelukast 10 mg in chronic urticaria resistant to levocetirizine 5 mg: A double-blind, randomized, controlled trial” by Sarkar et al
Abstract
© 2017 Indian Journal of Dermatology, Venereology and Leprology | Published by Wolters Kluwer Medknow Sir, Current international guidelines on managing chronic urticaria are based on evidence from published literature where available. However, there is a scarcity of clinical trials even among well‐established therapeutic options. We thank the authors for addressing an important evidence gap by conducting a randomized controlled trial to test the comparability of a standard dose of levocetirizine 5 mg plus montelukast 10 mg and doubling the dose of levocetirizine to 10 mg. We wish to share a number of observations that would benefit from some clarification from the authors.
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Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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