AAAAI physician survey: Current antihistamine use in the clinical setting
Abstract
Background: First-generation antihistamines (FGAs) are less selective for histamine receptor binding than second-generation antihistamines (SGA), with a resulting increased risk for untoward effects. Real-world use data by allergists and immunologists of FGAs versus SGAs is lacking in the literature.
Objective: We assessed FGA versus SGA preference patterns and clinical uses by practicing allergists and immunologists in the United States.
Methods: An anonymous survey was distributed by the AAAAI Practice, Diagnostics, and Therapeutics Committee to practicing member allergists and immunologists.
Results: A total of 702 surveys were distributed with 85 respondents (12.1% response rate). Respondents practiced most commonly in private practice (55%, n = 45) and academic settings (34.57%, n = 28). Situation/location-specific preferences for using FGAs versus SGAs were reported: for in-office challenges, 66.67% (n = 50) preferred SGAs. Further, 64.47% (n = 49) preferred SGAs for home allergy action plans and 58.44% (n = 45) for school allergy action plans. Regarding complementary use in eczema, 44.74% (n = 34) preferred SGAs, 15.79% (n = 12) preferred FGAs, and 39.47% (n = 30) reported using both. There was a significant difference in preference between FGAs and SGAs based on years in practice, with those practicing for <10 years more likely to prefer SGAs.
Conclusion: Variable use of FGAs versus SGAs exists among practicing allergists, demonstrating the need to improve education…
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