Exploring the relationship and shared mechanisms of major depressive disorder and diabetic kidney disease: a comprehensive clinical and genetic analysis
Abstract
Introduction: Major depressive disorder (MDD) is a common comorbidity in diabetes mellitus (DM), while diabetic kidney disease (DKD) represents a severe complication of DM. However, the clinical and genetic associations between MDD and DKD remain unclear. This study aimed to investigate their shared biomarkers, molecular pathways, and immune features.
Methods: We analyzed data from the National Health and Nutrition Examination Survey (NHANES, 2005-2018) to assess the association between MDD and DKD. Genetic correlation was evaluated using linkage disequilibrium score regression (LDSC), and causality was tested with Mendelian randomization (MR). Gene expression datasets were integrated to identify crosstalk genes, followed by protein-protein interaction (PPI) analysis to detect hub genes. Diagnostic performance was validated using least absolute shrinkage and selection operator (LASSO) regression and receiver operating characteristic (ROC) curves. Immune infiltration was assessed, and potential therapeutic compounds were predicted through connectivity map (cMAP) analysis and molecular docking.
Results: Clinical analysis revealed a significant association between MDD and DKD (OR = 1.45, 95% CI: 1.28-1.64). LDSC indicated a significant genetic correlation (r = 0.2153, P = 0.008), although MR analysis did not support a causal relationship. A total of 83 crosstalk genes were identified, primarily enriched in inflammation and immune regulation pathways. PPI analysis highlighted…
Read the paper
Related studies
- Artificial Intelligence in Medicine: Cross-Sectional Study Among Medical Students on Application, Education, and Ethical Aspects
- Information quality of videos related to esophageal cancer on tiktok, kwai, and bilibili: a cross-sectional study
- The quality and reliability of short videos about hypertension on TikTok: a cross-sectional study
- Quality and reliability evaluation of pancreatic cancer-related video content on social short video platforms: a cross-sectional study
- Quality and reliability of pediatric pneumonia related short videos on mainstream platforms: cross-sectional study
- Association between metabolic score for insulin resistance (METS-IR) and hypertension: a cross-sectional study based on NHANES 2007–2018
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.