Efficacy and safety of Runzao Zhiyang capsules combined with antihistamines in the treatment of chronic eczema: A meta-analysis
Abstract
Background: This meta-analysis aims to evaluate the effects of Runzao Zhiyang capsules (RZC) plus antihistamines (AHs) for chronic eczema.
Methods: A search involving 8 databases were conducted to collect studies on RZC with AHs for chronic eczema from inception to July 2024.
Results: Thirty-two studies with 3071 participants were identified in this meta-analysis. Compared to the AHs group, the total effective rate of the RZC group was higher (relative risk [RR] = 1.30, 95% confidence interval [CI] = 1.24-1.36, P < .001) and a lower recurrence rate (RR = 0.33, 95% CI = 0.21-0.51, P < .001). The RZC group demonstrated better outcomes in the Eczema Area and Severity Index (mean difference [MD] = -1.44, 95% CI = -2.18 to -0.70, P < .001), severity of pruritus (MD = -0.24, 95% CI = -0.32 to -0.15, P < .001), and serum total IgE level (MD = -18.80, 95% CI = -25.20 to -12.40, P < .001). With respect to safety, the RZC group exhibited a reduced incidence of drowsiness (RR = 0.50, 95% CI = 0.28-0.87, P = .01), while the incidences of headache, dizziness, and gastrointestinal discomfort did not differ significantly from the AHs group (RR = 0.93, 95% CI = 0.46-1.90, P = .85); (RR = 1.41, 95% CI = 0.71-2.79, P = .32).
Conclusion: RZC when added to conventional AHs, further enhance the treatment efficacy for chronic eczema and significantly reduce the incidence of drowsiness.
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 3,071 participants or records.
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