Treatment of chronic urticaria with traditional Chinese medicine: A systematic review, meta-analysis, and medication regularity
Abstract
Background: Traditional Chinese medicine (TCM) is often used to treat chronic urticarial (CU), so its efficacy and safety on CU were studied according to systematic review and meta-analysis.
Methods: By searching PubMed, Wanfang, CNKI, and other databases for the literature on the treatment of CU with TCM in the past 10 years (2013-2023), the PICOS principle was used as the criterion for inclusion and exclusion of literature, and the quality of the included literature studies was systematically reviewed according to the Cochrane systematic review method and software RevMan5.3.
Results: A total of 14 articles were included, including 1192 patients. According to the analysis results, the total effective rate of TCM in the treatment of CU was (RR = 1.23, 95% confidence interval (CI) [1.16-1.29], P < .00001), the incidence of adverse reactions and recurrence rates were (RR = 0.23, 95% CI [0.13-0.39], P < .00001) and (RR = 0.24, 95% CI [0.13-0.43], P < .00001), and the symptom score was (MD = -0.38, 95% CI [-0.81-0.05], P = .08). The most frequently used Chinese herbs were Windbreak, Licorice, Angelica sinensis, Schizonepeta, Cicada slough, Cassia twig, Astragalus membranaceus, schisandra chinensis, Cortex dictamni and Dark plum.
Conclusion: TCM has great advantages in the treatment of CU, can effectively improve the symptoms, the curative effect is stable and safe, but there are still some deficiencies in the standardization of curative effect evaluation.
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 1,192 participants or records.
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