Piperacillin - Tazobactam -induce Allergic Reactions: A Case Study of a 70-year-old Female Patient
Abstract
ADRs are an important issue in clinical practice, more so in geriatric patients receiving broad-spectrum antibiotic therapy. This case report discusses a 70-year-old woman who had an allergic reaction with generalized itching after the administration of Injection Piptaz (Piperacillin + Tazobactam) for some abdominal symptoms that had persisted for some days. It was initially treated with analgesics, gastric protectants, antibiotics, and antiparasitic agents. Afterward, the situation called for an additional intervention. Using the Naranjo Scale, the reaction was found to have a score above nine; hence, this was labeled a definite ADR. The offending drug, Piptaz, was immediately stopped, and then, antihistamine Levocetirizine and another antibiotic, Amikacin, were given, with symptoms subsiding thereafter. This case strengthens the evidence for constant ADR monitoring, especially in cases of polypharmacy, which are common among the elderly. Objective scales, such as the Naranjo Scale, are recommended for timely detection and mitigation of ADRs, thereby averting adverse clinical effects.
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