Antihistamines reduce initial flaring and speed improvement during isotretinoin treatment for acne: A systematic review and meta-analysis
Abstract
Acne vulgaris is estimated to affect up to 10% of the world’s population.1 Recent literature has shown a significant decrease in side effects with isotretinoin treatment when combined with H1 antihistamines and a greater reduction in acneiform lesions.2,3 The purpose of this paper is to combine and analyze the results of pilot studies analyzing the reduction in skin purging in patient groups treated with a combination of H1 antihistamines and systemic retinoids.
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Evidence Hub reads this as a meta-analysis. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
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