The formulation and evaluation of mouth dissolving tablet Levocetirizine by using synthetic Superdisintegrants
Abstract
Aim of this research work was to develop mouth dissolving tablet that disintegrates rapidly in mouth by using tasteless complex of Levocetirizine and β-CD. Mouth dissolving Tablets also called as Orodispersible tablets. Formulated Levocetirizine β-CD complex was characterized by infrared spectroscopy, thermal analysis and X-ray diffraction pattern. Tablets were developed by direct compression method. Superdisintegrants like Sodium starch glycolate (SSG), Crosscarmellose sodium (CCS) and Crosspovidone (CP) were used for the formulation. Every formulation was subjected to in-vitro tests like wetting time, disintegration test and dissolution test. The in-vitro study showed that increasing the concentration of superdisintegrants lowers the wetting time (WT) and disintegration time (DT) and enhances the drug release percentage of the formulations.
The formulation CPX5 was the most effective formulation as it showed wetting time of 12 seconds, disintegration time of 20 seconds and cumulative % drug release of 41 and 99% at 1 and 10 minutes respectively. The study showed that the formulations containing SSG and CP as the superdisintegrants showed better drug release pattern than the formulations with other superdisintegrants. The study also showed that SSG as the superdisintegrant was more effective for the formulation of orodispersible tablets of levocetirizine dihydrochloride
Read the paper
Related studies
- Artificial Intelligence in Medicine: Cross-Sectional Study Among Medical Students on Application, Education, and Ethical Aspects
- Information quality of videos related to esophageal cancer on tiktok, kwai, and bilibili: a cross-sectional study
- The quality and reliability of short videos about hypertension on TikTok: a cross-sectional study
- Quality and reliability evaluation of pancreatic cancer-related video content on social short video platforms: a cross-sectional study
- Quality and reliability of pediatric pneumonia related short videos on mainstream platforms: cross-sectional study
- Association between metabolic score for insulin resistance (METS-IR) and hypertension: a cross-sectional study based on NHANES 2007–2018
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.