Development and characterization of novel in-situ floating gel of levocetirizine dihydrochloride for oral drug delivery system
Abstract
Floating in-situ floating gel system of Levocetirizine Dihydrochloride was prepared using sodium alginate as a gelling polymer and calcium carbonate as floating agent for potentially prevent the Belgaum formation and to offer extended release, associated with the itching, runny nose and sneezing or sometimes vertigo caused problems to inner ear. Floating in-situ gel was prepared by dissolving various concentrations of sodium alginate in deionized water to which various concentration of floating agent dispersed well. The formulation parameters like concentration of sodium alginate influenced the rate and extent of in-vitro drug release significantly from floating in-situ gel. the evaluation parameters was carried out with the help of various studies like physical appearance, pH, viscosity, drug content, floating duration ,floating lag time, in-vitro drug release study, kinetic models and stability studies. Floating In-Situ Gel had shown all the evaluation parameters to offer sustained release and better therapeutic effect.
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