Formulation and evaluation of taste masked orodispersible tablet of levocetirizine dihydrochloride
Abstract
The objective of present investigation was to prepare and evaluate taste masked orodispersible tablet of levocetirizine dihydrochloride using superdisintegrants crospovidone and sodium starch glycolate for the treatment of allergic rhinitis. The taste masking technique employed was ionexchange resin whereas tableting was done using direct compression method. Prepared tablets were evaluated for weight variation, hardness, friability, content uniformity, wetting time, in vitro disintegration time, water absorption ratio and stability studies. Among developed formulations, disintegration time was found to be rapid in F4 formulation. The in vitro dissolution studies showed that F4 formulation released 99.73% of drug in 10 min. Moreover, F4 formulation was found to be stable and retained its original properties during the testing period.
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