Controlled release formulation of levocetirizine dihydrochloride by casein microparticles
Abstract
The study aims to develop a microparticulate casein based delivery system by the controlled drug delivery approach using Levocetirizine dihydrochloride as the model drug. Fourier transform infrared spectroscopy (FTIR), X-ray and differential scanning calorimetry (DSC) studies substantially indicates the presence of molecularly dispersed drug within the particles with preserved stability during microencapsulation. In vitro release studies of levocetirizine dihydrochloride loaded microparticles were performed by simulating the condition of gastrointestinal tract, and showed the minimal drug leakage (less than 5%) at acidic pH (1.2) and significantly higher release at basic pH (7.4). The results were found to be critical in confirming the role of casein microparticles as potential candidate for the controlled and targeted release of levocetirizine dihydrochloride.
Key words: Extended release, casein, levocetirizine dihydrochloride, steric stabilization.
Read the paper
Related studies
- Artificial Intelligence in Medicine: Cross-Sectional Study Among Medical Students on Application, Education, and Ethical Aspects
- Information quality of videos related to esophageal cancer on tiktok, kwai, and bilibili: a cross-sectional study
- The quality and reliability of short videos about hypertension on TikTok: a cross-sectional study
- Quality and reliability evaluation of pancreatic cancer-related video content on social short video platforms: a cross-sectional study
- Quality and reliability of pediatric pneumonia related short videos on mainstream platforms: cross-sectional study
- Association between metabolic score for insulin resistance (METS-IR) and hypertension: a cross-sectional study based on NHANES 2007–2018
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.