Oral Spray: Comparative Study Of Drug Release In Different Dosage Form Of Levocetrizine Dihydrochloride
Abstract
Objective: Levocetirizine dihydrochloride is also known as “Xyzol.” Levocetirizine dihydrochloride is a second-generation piperazine derivative, potent H1 selective agent. Levocetirizine dihydrochloride is the active R (-) enantiomer of cetirizine dihydrochloride. In the case of an allergic or histaminic reaction, the medication must respond rapidly. Many older patients, infants, and dysphagia patients have trouble swallowing traditional tablets or capsules. Hence, a need exists for a relatively fast-acting oral spray form. Methods: The oral spray were prepared by direct dissolving drug component into water with added buffering agents, sweetening agent, preservative and flavors. Then, the spray was filled in suitable plastic container having the spray device. The tablets was prepared with granulation technique by mixing of drug component with suitable Disintegrating and binding agents followed by compression. Oral spray was evaluated for comparative in vitro Dissolution and Diffusion test against tablet form. Results: The oral spray demonstrates significantly faster drug availability, with complete dissolution occurring in less than 5 minutes. Diffusion study suggest that the oral spray formulation facilitates quicker drug availability in solution compared to other delivery methods. The rapid diffusion could enhance the onset of action, making it a favorable option for achieving faster therapeutic effects. Conclusion: Comparative Dissolution and Diffusion study suggest that…
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