Anti‐inflammatory properties of antihistamines: an update
Abstract
Summary Since histamine plays a prominent and diverse role in the pathophysiology of allergic disease, therapeutic intervention is usually focused on blocking the effects of this biogenic amine. Studies investigating the mechanisms underlying the effects of H1 antihistamines have demonstrated that a number of agents in this drug class possess anti‐allergic/anti‐inflammatory properties, in addition to their antihistaminic properties, which may partly explain the high efficacy of these drugs in the treatment of allergic disease with an underlying inflammatory pathology. However, with some exceptions, the majority of anti‐allergic/anti‐inflammatory effects observed in vitro are noted at concentrations that are several hundred‐fold higher than therapeutic levels and are therefore clinically irrelevant. Additionally, it is clear that the H1 antihistamines differ with regard to their anti‐allergic/anti‐inflammatory potencies in vitro and in vivo. In this regard, both cetirizine and levocetirizine have been shown to have anti‐inflammatory/anti‐allergic activities at therapeutically relevant concentrations, in vitro and in vivo. Studies investigating the effect of long‐term treatment with cetirizine and levocetirizine have indicated that while cetirizine delays the onset, and, in some cases, prevents the development of asthma in children with atopic dermatitis at high risk of developing asthma, levocetirizine significantly improves the quality of life (QOL) in patients with…
Read the paper
Related studies
- Artificial Intelligence in Medicine: Cross-Sectional Study Among Medical Students on Application, Education, and Ethical Aspects
- Information quality of videos related to esophageal cancer on tiktok, kwai, and bilibili: a cross-sectional study
- The quality and reliability of short videos about hypertension on TikTok: a cross-sectional study
- Quality and reliability evaluation of pancreatic cancer-related video content on social short video platforms: a cross-sectional study
- Quality and reliability of pediatric pneumonia related short videos on mainstream platforms: cross-sectional study
- Association between metabolic score for insulin resistance (METS-IR) and hypertension: a cross-sectional study based on NHANES 2007–2018
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.