Formulation and Evaluation of Levocetirizine Gastro-Retentive Floating Tablets
Abstract
The purpose of this research work was to develop gastro retentive drug delivery system of Levocetirizine Floating tablets were prepared by direct compression method using gas generating agents such as sodium bicarbonate and citric acid anhydrous, polymers like Carbopol 934, Locust bean gum and HPMC K 100. Formulations tried for different ratios of drug and polymers to get desired release profile. Prepared tablets (LV1-LV9) were evaluated in terms of pre-compression and post compression parameters Levocetirizine floating tablets were prepared by direct compression method were found to be good without chipping, capping and sticking. The drug content was uniform in all the tablet formulations indicating uniform distribution of drug within the matrices. All the prepared batches showed satisfactory floating lag time and total floating time found to be more than 12hrs. Among all formulations, LV6 showed the drug release in most sustained manner and showed 99.14% of in vitro drug release at the end of 12 hrs and selected as the best formulation. The in vitro data obtained for the optimized formulation (LV6) was fitted in different models viz. zero order, first order, Higuchi and Korsemeyer-Peppas equation for release kinetics and showed that the formulation follows Peppas release mechanism Finally optimized formulation LV6 complying with all properties of floating tablets and found to be satisfactory.
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