Unraveling the Solvation Behavior of Levocetirizine Dihydrochloride: Insights from Volumetric, Acoustic, Viscometric, and Electronic Absorption Studies in Aqueous l -Proline and l -Valine Solutions
Abstract
The present article delves into the solvation behavior of levocetirizine dihydrochloride (LCTZ) in aqueous environments, thoroughly examining its interactions with two primary amino acids, l -proline and l -valine. This study spans the entire human body temperature range of 288.15–318.15 K, shedding light on the molecular dynamics and properties of LCTZ in the presence and absence of these amino acids. The investigation explores the volumetric, acoustic, viscometric, and electronic absorption properties of the system, along with extensive calculations of various thermodynamic and transport parameters of significance. The preponderance of hydrophobic associations of LCTZ with the water structure along with the dominant amino acid–LCTZ interaction surfaces out of the volumetric analysis, wherein viscometric and compressibility studies offer further support to the speculation. In the same vein, the sign of the temperature derivative of the B coefficient as well as that of Hepler’s constant underscores the chaotropic trait of studied molecules. The research thus contributes to a comprehensive understanding of intricate associations between LCTZ and the amino acids, unveiling the plausible intermolecular phenomenon for potential applications in drug delivery platforms. In this investigation, an attempt has been made to fill the gap in the existing literature, opening avenues for further research in this area.
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